Question · asked by 1 review
rs1126478 genotype distribution vs Caries-free control genotype distribution: Dental caries (by severity)
- Population
- Human subjects stratified by dental caries severity and caries-free controls
- Intervention
- rs1126478 genotype distribution
- Comparison
- Caries-free control genotype distribution
- Outcome
- Dental caries (by severity)
rs1126478 was inversely associated with low-level dental caries in a single study (OR 0.65, 95% CI 0.47 to 0.90; ungraded).
What each review found
Include earlier review versionsNo studies found 0 · 0%GRADE not reported 6 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
rs1126478 genotype distribution vs Caries-free control genotype distribution Dental caries (by severity) · Human subjects stratified by dental caries severity and caries-free controls · European countries, Low caries (DMFT 1); Volckova et al. 2014 rs1126478 was inversely associated with low-level dental caries in a single study (OR 0.65, 95% CI 0.47 to 0.90; ungraded). The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) All outcomes | OR 0.65 [0.47, 0.90] | 1 study | GRADE not reported |
rs1126478 genotype distribution vs Caries-free control genotype distribution Dental caries (by severity) · Human subjects stratified by dental caries severity and caries-free controls · European countries, Severe/high caries (DMFT 4 or more); Volckova et al. 2014 rs1126478 showed no significant association with severe-level dental caries in a single study (OR 1.20, 95% CI 0.94 to 1.54; ungraded). The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) All outcomes | OR 1.20 [0.94, 1.54] | 1 study | GRADE not reported |
rs1126478 genotype distribution vs Caries-free control genotype distribution Dental caries (by severity) · Human subjects stratified by dental caries severity and caries-free controls · European countries, Moderate caries (DMFT 2 to 3); Volckova et al. 2014 rs1126478 showed no significant association with moderate-level dental caries in a single study (OR 1.04, 95% CI 0.80 to 1.34; ungraded). The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) All outcomes | OR 1.04 [0.80, 1.34] | 1 study | GRADE not reported |
rs1126478 genotype distribution vs Caries-free control genotype distribution Dental caries (by severity) · Human subjects stratified by dental caries severity and caries-free controls · China, Severe caries (DMFT 13 to 20); Wang et al. 2018 rs1126478 was significantly associated with severe-level dental caries in a single study (OR 0.78, 95% CI 0.70 to 0.87; ungraded). The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) All outcomes | OR 0.78 [0.70, 0.87] | 1 study | GRADE not reported |
rs1126478 genotype distribution vs Caries-free control genotype distribution Dental caries (by severity) · Human subjects stratified by dental caries severity and caries-free controls · China, Moderate caries (DMFT 8 to 12); Wang et al. 2018 rs1126478 was significantly associated with moderate-level dental caries in a single study (OR 0.72, 95% CI 0.65 to 0.80; ungraded). The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) All outcomes | OR 0.72 [0.65, 0.80] | 1 study | GRADE not reported |
rs1126478 genotype distribution vs Caries-free control genotype distribution Dental caries (by severity) · Human subjects stratified by dental caries severity and caries-free controls · European countries, Moderate or severe caries combined; Volckova et al. 2014 rs1126478 was significantly associated with combined moderate-or-severe dental caries in a single study (OR 1.88, 95% CI 1.50 to 2.37; ungraded). The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) All outcomes | OR 1.88 [1.50, 2.37] | 1 study | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based analysis. 2020 All outcomes | December 5, 2019 (papers published before this date) | 6 | Not applicable |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.