Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,038 questions · 2,118 findings · 339 reviews

No studies found 323 · 15.3%GRADE not reported 166 · 7.8%Very low 552 · 26.1%Low 592 · 28%Moderate 340 · 16.1%High 145 · 6.8%

Vaginal PGE2 vs intravenous (IV) oxytocin

Caesarean section · women with one previous lower segment caesarean section and requiring labour induction due to prolonged pregnancy or pre‐eclampsia,…

Vaginal PGE2 showed no clear difference in caesarean section compared with intravenous (IV) oxytocin (low certainty).

1 finding from 1 review

80 mL vs Foley catheter

Vaginal delivery not achieved within 24 hours · pregnant women who previously had a lower segment CS and now have a singleton cephalic presentation after at least 36 completed weeks, not…

80 mL showed no clear difference in vaginal delivery not achieved within 24 hours compared with 30 mL Foley catheter (moderate certainty).

1 finding from 1 review

Vaginal PGE2 vs intravenous (IV) oxytocin

Serious neonatal morbidity or perinatal death · women with one previous lower segment caesarean section and requiring labour induction due to prolonged pregnancy or pre‐eclampsia,…

Vaginal PGE2 showed no clear difference in serious neonatal morbidity/perinatal death compared with intravenous (IV) oxytocin (low certainty).

1 finding from 1 review

Vaginal PGE2 vs intravenous (IV) oxytocin

Serious maternal morbidity or death · women with one previous lower segment caesarean section and requiring labour induction due to prolonged pregnancy or pre‐eclampsia,…

Vaginal PGE2 showed no clear difference in serious maternal morbidity or death compared with intravenous (IV) oxytocin (low certainty).

1 finding from 1 review

Higher BP target (< 150‐160/95‐105 mmHg) vs lower BP target (< 140/90 mmHg)

Serious adverse events: cardiovascular events · older adults with primary hypertension

Higher BP target (< 150‐160/95‐105 mmHg) showed no clear difference in cardiovascular serious adverse events compared with lower BP target (< 140/90 mmHg) (low certainty).

1 finding from 1 review

Granulocyte-macrophage colony-stimulating factor (GM-CSF), higher dose (1260 to 12,600 micrograms) vs Granulocyte-macrophage colony-stimulating factor (GM-CSF), lower dose (12.6 to 126 micrograms)

Oral mucositis (severe) · breast cancer patients undergoing chemotherapy

Granulocyte-macrophage colony-stimulating factor (GM-CSF), higher… led to higher oral mucositis (severe) compared with granulocyte-macrophage colony-stimulating factor (GM-CSF), lower…; GRADE not reported.

1 finding from 1 review