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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Every word you type has to appear somewhere in the question, and the closest matches are ranked first.
5,762 questions in 263 reviews · Dental caries
current versionsNo studies 321 · 5.6%Ungraded 4,450 · 77.2%Very low 455 · 7.9%Low 297 · 5.2%Moderate 200 · 3.5%High 39 · 0.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intraglandular botulinum neurotoxin (BoNT) injection vs No BoNT (placebo or pre-treatment baseline) Oral/salivary pH · Patients with drooling (sialorrhea) due to neurological disease · Before vs after BoNT injection Oral health effects of botulinum toxin treatment for drooling: a systematic review. (2020) | Wu et al. did not observe significant differences in participants' oral pH before and after BoNT-A injections between the active and control groups. There were also no statistically significant differences regarding… | 3 studies | Ungraded |
All fluorescence-based devices (red, blue, and green fluorescence combined) vs Reference standard: histology, enhanced visual examination with or without radiographs, or excavation Diagnostic odds ratio (DOR) by subgroup: Low dentine-caries prevalence (<=14%) (detection of early enamel caries, D1 threshold) · Children or adults presenting asymptomatically or suspected of having enamel caries (in vivo/clinical studies);… · Up to 3 months between index test and reference standard (in vivo studies), Low dentine-caries prevalence (<=14%) Fluorescence devices for the detection of dental caries (2020) · Cochrane | DOR 11.10 [6.88, 17.91] | NR | Ungraded |
GERD vs Healthy individuals without reflux (controls) Dental caries (Decayed Missing Filled index) · Adults with gastroesophageal reflux disease (GERD) or laryngopharyngeal reflux (LPR) Laryngopharyngeal reflux, gastroesophageal reflux and dental disorders: A systematic review. (2020) | Three studies reported higher decayed-missing-filled index scores or a positive association between GERD and caries compared with controls (Yoshikawa, Song, Watanabe); no pooled estimate. | 3 studies | Ungraded |
T allele of AMELX rs946252 vs C allele of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Low caries Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.99 [0.53, 1.86] | 1 study | Ungraded |
TT genotype of AMELX rs17878486 vs CC + CT genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Low caries Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.44 [0.75, 2.77] | 2 studies | Ungraded |
CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Asian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.89 [0.04, 22.53] | 1 study | Ungraded |
CT genotype of ENAM rs3796703 vs CC genotype of ENAM rs3796703 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Asian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.89 [0.23, 3.48] | 2 studies | Ungraded |
GG genotype of LTF rs1126478 vs AA + AG genotype of LTF rs1126478 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.33 [0.77, 2.29] | 2 studies | Ungraded |
T allele of AMELX rs946252 vs C allele of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.21 [0.77, 1.91] | 2 studies | Ungraded |
G allele of ENAM rs3796704 vs A allele of ENAM rs3796704 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.43 [1.10, 1.85] | 3 studies | Ungraded |
Canary System (Quantum Dental Technologies; red fluorescence, scale 0-100) vs Reference standard: histology, enhanced visual examination with or without radiographs, or excavation Outcome NR · Children or adults presenting asymptomatically or suspected of having enamel caries (in vivo/clinical studies);… · Up to 3 months between index test and reference standard (in vivo studies) Fluorescence devices for the detection of dental caries (2020) · Cochrane | The Canary System was not used by any included study. | 0 studies | No studies |
TT genotype of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 4.69 [0.55, 40.16] | 3 studies | Ungraded |
All fluorescence-based devices (red, blue, and green fluorescence combined) vs Reference standard: histology, enhanced visual examination with or without radiographs, or excavation Sensitivity at fixed upper-quartile specificity 0.90 (detection of early enamel caries, D1 threshold) · Children or adults presenting asymptomatically or suspected of having enamel caries (in vivo/clinical studies);… · Up to 3 months between index test and reference standard (in vivo studies) Fluorescence devices for the detection of dental caries (2020) · Cochrane | Sensitivity 0.60 [0.54, 0.65] | 79 studies | Low |
AG + GG genotype (G-allele carriers) of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.16 [0.76, 1.75] | 4 studies | Ungraded |
GG genotype of ENAM rs1264848 vs AA + AG genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.83 [0.44, 1.58] | 5 studies · 1534 participants | Ungraded |
Preterm birth (<37 weeks gestation) vs Full-term birth (37 weeks or more gestation) Early childhood caries (ECC) · Children aged 6 years or younger (preschool children) · Children aged 3 years or younger Relationship between preterm, low birth weight and early childhood caries: a meta-analysis of the… (2020) | OR 0.90 [0.59, 1.37] | 2 studies | Ungraded |
TT genotype of ENAM rs3796703 vs CC genotype of ENAM rs3796703 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Asian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 5.22 [0.25, 108.96] | 2 studies | Ungraded |
Tooth-coloured direct restorative materials (composite, compomer, giomer, RMGIC, HVGIC, open-sandwich) vs No comparator group (single-arm pooled success rate; materials/techniques contrasted via moderator analyses) Retention success rate · Children with primary molars requiring proximal (Class II) restorations · 24 months, Random assignment: No/Incorrect Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.897 [0.792, 0.952] | 12 studies | Ungraded |
All exposure-OHRQoL estimates pooled for publication-bias correction (meta-trim sensitivity); specific exposure set not defined in source vs Not specified Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years · Trim-and-fill adjusted (publication-bias corrected), random-effects The Association of Oral Health Status, demographic characteristics and socioeconomic determinants with Oral… (2020) | OR 0.17 [0.13, 0.21] | NR | Ungraded |
Intervention NR Marginal integrity success rate · Use of cavity conditioner: No Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.963 [0.779, 0.995] | 2 studies | Ungraded |
LTF rs1126478 GG genotype vs AA genotype Dental caries susceptibility · Age group: Children (n=4) individuals with caries/high caries and controls · Age group: Children (n=4) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.03 [0.80, 1.33] | 4 studies | Ungraded |
AMELX rs17878486 TT genotype vs CC genotype Dental caries susceptibility · Ethnicity: Caucasian (n=2) individuals with caries/high caries and controls · Ethnicity: Caucasian (n=2) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 5.12 [0.09, 278.85] | 2 studies | Ungraded |
Intervention NR Anatomic form success rate · Study design: Noncontrolled trial Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.950 [0.867, 0.982] | 4 studies | Ungraded |
Combined index test: visual examination + radiograph + DIAGNOdent (Alomari 2015) vs Reference standard: histology Sensitivity for detection of early enamel caries (D1 threshold) · Children or adults presenting asymptomatically or suspected of having enamel caries (in vivo/clinical studies);… · Up to 3 months between index test and reference standard (in vivo studies) Fluorescence devices for the detection of dental caries (2020) · Cochrane | Sensitivity 0.82 [0.75, 0.88] | 1 study | Ungraded |
Resin-based fissure sealant plus fluoride varnish vs Fluoride varnish alone Progression of dentinal carious lesions into enamel or dentine · Children and adolescents from the general population, younger than 20 years of age at the start of the study Pit and fissure sealants versus fluoride varnishes for preventing dental decay in the permanent teeth of… (2020) · Cochrane | The study (Splieth 2001) did not report progression of dentinal carious lesions into enamel or dentine. | 0 studies | No studies |
AG genotype of ENAM rs3796704 vs AA genotype of ENAM rs3796704 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Caries-free Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.74 [0.81, 3.74] | 2 studies | Ungraded |
CT + TT genotype (T-allele carriers) of AMELX rs946252 vs CC genotype of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.24 [0.66, 2.33] | 2 studies | Ungraded |
AMELX rs2106416 TT genotype vs CC + CT genotype Dental caries susceptibility · Individuals with caries/high caries and caries-free or low-caries controls · Overall (n=3) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.67 [0.44, 6.34] | 3 studies · 285 participants | Ungraded |
G allele of ENAM rs3796704 vs A allele of ENAM rs3796704 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Low caries Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.97 [0.63, 1.50] | 2 studies | Ungraded |
Intervention NR Anatomic form success rate · Material type: Resin-modified glass ionomer cement (RMGIC) Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.934 [0.848, 0.973] | 5 studies | Ungraded |
Intervention NR Marginal integrity success rate · Material type: Resin-based material + self-etching adhesion Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.916 [0.848, 0.956] | 8 studies | Ungraded |
T allele of AMELX rs17878486 vs C allele of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 2.25 [0.81, 6.24] | 4 studies · 442 participants | Ungraded |
Intervention NR Anatomic form success rate · Material type: Resin-based material + self-etching adhesion Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.926 [0.829, 0.970] | 6 studies | Ungraded |
Intervention NR Anatomic form success rate · Financial source: Public Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.919 [0.846, 0.959] | 10 studies | Ungraded |
AMELX rs6639060 CT + TT genotype vs CC genotype Dental caries susceptibility · Ethnicity: Caucasian (n=1) individuals with caries/high caries and controls · Ethnicity: Caucasian (n=1) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.14 [0.56, 2.29] | 1 study | Ungraded |
T allele of AMELX rs17878486 vs C allele of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Mixed Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.87 [1.06, 3.30] | 1 study | Ungraded |
Periodontal disease (present) vs No periodontal disease Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years The Association of Oral Health Status, demographic characteristics and socioeconomic determinants with Oral… (2020) | OR 1.15 [1.12, 1.18] | 3 studies | Ungraded |
AG genotype of ENAM rs3796704 vs AA genotype of ENAM rs3796704 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.74 [0.81, 3.74] | 3 studies | Ungraded |
CT + TT genotype (T-allele carriers) of ENAM rs3796703 vs CC genotype of ENAM rs3796703 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.90 [0.23, 3.63] | 2 studies · 1152 participants | Ungraded |
Tooth-coloured direct restorative materials (composite, compomer, giomer, RMGIC, HVGIC, open-sandwich) vs No comparator group (single-arm pooled success rate; materials/techniques contrasted via moderator analyses) Absence of recurrent caries success rate · Children with primary molars requiring proximal (Class II) restorations · 24 months, Trim-and-fill adjusted (publication-bias sensitivity) Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.878 [0.828, 0.915] | 38 (30 observed + 8 imputed) studies | Ungraded |
Vegetarian diet (any diet excluding all meat, poultry and fish) vs Nonvegetarian diet Presence of dental erosion · General population (children and adults) assessed for dental hard-tissue health Vegetarian diet and its possible influence on dental health: A systematic literature review. (2020) | OR 2.40 [1.24, 4.66] | 6 studies | Ungraded |
AMELX rs946252 TT genotype vs CC genotype Dental caries susceptibility · Ethnicity: Mixed (n=1) individuals with caries/high caries and controls · Ethnicity: Mixed (n=1) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.03 [0.28, 3.75] | 1 study | Ungraded |
AG + GG genotype (G-allele carriers) of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.18 [0.86, 1.62] | 4 studies | Ungraded |
Female gender (girls) vs Male gender (boys) Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years The Association of Oral Health Status, demographic characteristics and socioeconomic determinants with Oral… (2020) | OR 1.13 [1.09, 1.17] | 3 studies | Ungraded |
Tooth-coloured direct restorative materials (composite, compomer, giomer, RMGIC, HVGIC, open-sandwich) vs No comparator group (single-arm pooled success rate; materials/techniques contrasted via moderator analyses) Retention success rate · Children with primary molars requiring proximal (Class II) restorations · 24 months, Material type: Resin-modified glass ionomer cement (RMGIC) Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.956 [0.865, 0.986] | 5 studies | Ungraded |
GG genotype of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Caries-free Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.42 [0.03, 5.41] | 3 studies | Ungraded |
TT genotype of AMELX rs6639060 vs CC + CT genotype of AMELX rs6639060 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.00 [0.42, 2.39] | 1 study | Ungraded |
CT genotype of ENAM rs3796703 vs CC genotype of ENAM rs3796703 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.89 [0.23, 3.48] | 2 studies | Ungraded |
ENAM rs3796703 TT genotype vs CC genotype Dental caries susceptibility · Ethnicity: Asian (n=2) individuals with caries/high caries and controls · Ethnicity: Asian (n=2) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 5.22 [0.25, 108.96] | 2 studies | Ungraded |
Higher dental caries experience vs Caries-free children Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years The Association of Oral Health Status, demographic characteristics and socioeconomic determinants with Oral… (2020) | OR 1.66 [1.43, 1.88] | 6 studies | Ungraded |