What do systematic reviews say?

1,655 questions · 1,751 findings · 147 reviews · Pain, Palliative and Supportive Care

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No studies found 361 · 20.6%GRADE not reported 87 · 5%Very low 625 · 35.7%Low 367 · 21%Moderate 232 · 13.2%High 79 · 4.5%

Intervention not reported

At least 50% of maximum pain relief over 4 to 6 h · adults with moderate or severe acute postoperative pain

The intervention leads to higher at least 50% of maximum pain relief over 4 to 6 h (high certainty).

1 finding from 1 review

Single dose oral ibuprofen plus codeine for acute postoperative pain in adults 2015 · Cochrane Headline outcomes only
RR 4.1 [2.8, 5.9]
Studies not reported
High

Intervention not reported

Participants with at least 1 adverse event · adults with moderate or severe acute postoperative pain

The intervention showed no clear difference in participants with at least 1 adverse event (moderate certainty).

1 finding from 1 review

Single dose oral ibuprofen plus codeine for acute postoperative pain in adults 2015 · Cochrane Headline outcomes only
RR 1.2 [0.84, 1.7]
Studies not reported
Moderate

Intervention not reported

Participants with a serious adverse event · adults with moderate or severe acute postoperative pain

The review found no eligible studies for this question.

1 finding from 1 review

Single dose oral ibuprofen plus codeine for acute postoperative pain in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Deaths · adults with moderate or severe acute postoperative pain

The review found no eligible studies for this question.

1 finding from 1 review

Single dose oral ibuprofen plus codeine for acute postoperative pain in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Pain at 1 week Scale from: 0 to 10 · adult patients with cancer‐related pain

1 finding from 1 review

Corticosteroids for the management of cancer‐related pain in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 315 participants
Low

Intervention not reported

Pain free at 2 hours · Adults with episodic tension‐type headache

1 finding from 1 review

Ibuprofen for acute treatment of episodic tension‐type headache in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 1052 participants
Moderate

Intervention not reported

Pain free at 1 hour · Adults with episodic tension‐type headache

1 finding from 1 review

Ibuprofen for acute treatment of episodic tension‐type headache in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 711 participants
Moderate

Intervention not reported

Global evaluation 'very good' or 'excellent' · Adults with episodic tension‐type headache

1 finding from 1 review

Ibuprofen for acute treatment of episodic tension‐type headache in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 739 participants
Moderate

Intervention not reported

Use of rescue medication over 6 hours · Adults with episodic tension‐type headache

1 finding from 1 review

Ibuprofen for acute treatment of episodic tension‐type headache in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 589 participants
Low

Intervention not reported

Adverse events · Adults with episodic tension‐type headache

1 finding from 1 review

Ibuprofen for acute treatment of episodic tension‐type headache in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 1645 participants
High

Intervention not reported

Serious adverse events · Adults with episodic tension‐type headache

1 finding from 1 review

Ibuprofen for acute treatment of episodic tension‐type headache in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Intervention not reported

At least 50% of maximum pain relief over 4 to 6 h · Adults with acute pain

The intervention probably leads to higher at least 50% of maximum pain relief over 4 to 6 h (moderate certainty).

1 finding from 1 review

Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults 2015 · Cochrane Headline outcomes only
RR 5.5 [3.5, 8.7]
4 studies · 334 participants
Moderate

Intervention not reported

Participants remedicating within 8 hours · Adults with acute pain

The intervention probably leads to lower participants remedicating within 8 hours (moderate certainty).

1 finding from 1 review

Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults 2015 · Cochrane Headline outcomes only
RR 0.5 [0.4, 0.6]
3 studies · 293 participants
Moderate

Intervention not reported

Participants with at least 1 adverse event · Adults with acute pain

The intervention showed no clear difference in participants with at least 1 adverse event (low certainty).

1 finding from 1 review

Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults 2015 · Cochrane Headline outcomes only
RR 1.9 [0.91, 3.8]
4 studies · 336 participants
Low

Intervention not reported

Participants with a serious adverse event · Adults with acute pain

1 finding from 1 review

Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 336 participants
Low

SSRIs or SNRIs vs placebo

Headache (frequency) · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 127 participants
Low

SSRIs or SNRIs vs other antidepressants

Headache duration (hours) · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 152 participants
Low

SSRIs or SNRIs vs other antidepressants

Symptomatic/analgesic medication use for acute headache attacks · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 152 participants
Low

SSRIs or SNRIs vs other antidepressants

Headache index · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 152 participants
Very low

SSRIs or SNRIs vs other antidepressants

Quality of life · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low