Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,550 questions · 1,617 findings · 161 reviews · Neonatal

No studies found 238 · 14.7%GRADE not reported 76 · 4.7%Very low 377 · 23.3%Low 567 · 35.1%Moderate 285 · 17.6%High 74 · 4.6%

Adjustable individualized fortification vs standard non‐individualized fortification

Culture‐proven late‐onset sepsis · promoting growth and development in very low birth weight infants receiving human milk

The review found no eligible studies for this question.

1 finding from 1 review

Targeted or adjustable individualized fortification vs standard non‐individualized fortification

Necrotising enterocolitis · promoting growth and development in very low birth weight infants receiving human milk

The review found no eligible studies for this question.

1 finding from 1 review

Targeted or adjustable individualized fortification vs standard non‐individualized fortification

Culture‐proven late‐onset sepsis · promoting growth and development in very low birth weight infants receiving human milk

The review found no eligible studies for this question.

1 finding from 1 review

Targeted or adjustable individualized fortification vs standard non‐individualized fortification

Bronchopulmonary dysplasia · promoting growth and development in very low birth weight infants receiving human milk

It is very uncertain whether targeted or adjustable individualized fortification changes bronchopulmonary dysplasia compared with standard non‐individualized fortification (very low certainty).

1 finding from 1 review

Targeted or adjustable individualized fortification vs standard non‐individualized fortification

Presence of osteopenia · promoting growth and development in very low birth weight infants receiving human milk

It is very uncertain whether targeted or adjustable individualized fortification changes osteopenia compared with standard non‐individualized fortification (very low certainty).

1 finding from 1 review

Intervention not reported

Any upper gastrointestinal bleeding in infants at risk of upper gastrointestinal bleeding · newborn infants at risk of gastrointestinal bleeding

The intervention probably leads to lower any upper gastrointestinal bleeding in infants at risk of upper… (moderate certainty).

1 finding from 1 review