Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,966 questions · 3,201 findings · 165 reviews

No studies found 25 · 0.8%GRADE not reported 2,717 · 84.9%Very low 167 · 5.2%Low 124 · 3.9%Moderate 132 · 4.1%High 36 · 1.1%

TT genotype of AMELX rs2106416 vs CC genotype of AMELX rs2106416

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between TT genotype vs CC genotype of AMELX rs2106416 and dental caries susceptibility (TT vs CC model: OR 1.83, 95% CI 0.47-7.06); certainty not graded.

3 findings from 1 review

TT genotype of ENAM rs3796703 vs CC + CT genotype of ENAM rs3796703

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between TT genotype vs CC + CT genotype of ENAM rs3796703 and dental caries susceptibility (TT vs CC + CT model: OR 2.90, 95% CI 0.92-9.12); certainty not graded.

3 findings from 1 review

T allele of AMELX rs2106416 vs C allele of AMELX rs2106416

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between T allele vs C allele of AMELX rs2106416 and dental caries susceptibility (T vs C model: OR 0.59, 95% CI 0.16-2.11); certainty not graded.

3 findings from 1 review

CT genotype of ENAM rs3796703 vs CC genotype of ENAM rs3796703

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between CT genotype vs CC genotype of ENAM rs3796703 and dental caries susceptibility (CT vs CC model: OR 0.89, 95% CI 0.23-3.48) in the Ethnicity: Asian subgroup; certainty not graded.

3 findings from 1 review

Preterm birth (<37 weeks gestation) vs Full-term birth (37 weeks or more gestation)

Early childhood caries (ECC) · Children aged 6 years or younger (preschool children)

In children aged 3 years or younger, preterm birth was not associated with early childhood caries (OR 0.90, 95% CI 0.59 to 1.37); certainty not graded.

2 findings from 1 review

TT genotype of ENAM rs3796703 vs CC genotype of ENAM rs3796703

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between TT genotype vs CC genotype of ENAM rs3796703 and dental caries susceptibility (TT vs CC model: OR 5.22, 95% CI 0.25-108.96) in the Ethnicity: Asian subgroup; certainty not graded.

3 findings from 1 review