evidencegaps
Question · asked by 1 review

TT genotype of AMELX rs2106416 vs CC genotype of AMELX rs2106416: Dental caries susceptibility

Population
Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
Intervention
TT genotype of AMELX rs2106416
Comparison
CC genotype of AMELX rs2106416
Outcome
Dental caries susceptibility

No significant association between TT genotype vs CC genotype of AMELX rs2106416 and dental caries susceptibility (TT vs CC model: OR 1.83, 95% CI 0.47-7.06); certainty not graded.

What each review found

Include earlier review versions
No studies found 0 · 0%GRADE not reported 3 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
FindingEffectStudiesGRADE certainty
TT genotype of AMELX rs2106416 vs CC genotype of AMELX rs2106416
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Case-control genetic association studies (multiple countries), Overall
No significant association between TT genotype vs CC genotype of AMELX rs2106416 and dental caries susceptibility (TT vs CC model: OR 1.83, 95% CI 0.47-7.06); certainty not graded.
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) All outcomes		OR 1.83 [0.47, 7.06]3 studies · 285 participantsGRADE not reported
TT genotype of AMELX rs2106416 vs CC genotype of AMELX rs2106416
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Case-control genetic association studies (multiple countries), Age group: Children
No significant association between TT genotype vs CC genotype of AMELX rs2106416 and dental caries susceptibility (TT vs CC model: OR 1.83, 95% CI 0.47-7.06) in the Age group: Children subgroup; certainty not graded.
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) All outcomes		OR 1.83 [0.47, 7.06]3 studiesGRADE not reported
TT genotype of AMELX rs2106416 vs CC genotype of AMELX rs2106416
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Case-control genetic association studies (multiple countries), Ethnicity: Caucasian
No significant association between TT genotype vs CC genotype of AMELX rs2106416 and dental caries susceptibility (TT vs CC model: OR 1.83, 95% CI 0.47-7.06) in the Ethnicity: Caucasian subgroup; certainty not graded.
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) All outcomes		OR 1.83 [0.47, 7.06]2 studiesGRADE not reported

Findings are shown side by side, never pooled across reviews.

The reviews

ReviewSearched up toIncluded studiesAMSTAR 2
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis.
2020 All outcomes
Up to October 201916Not applicable

The same intervention and outcome, asked in another population or against another comparator.

How reviews are matched to this question

Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.