Dry mouth (xerostomia) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
The review found no eligible studies for this question.
1 finding from 1 review
Salivary flow rate · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
The review found no eligible studies for this question.
1 finding from 1 review
Clinical resolution (oral lesion not completely resolved) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
Malignant transformation (oral cancer development) · People with a diagnosis of oral leukoplakia
It is very uncertain whether vitamin A or retinoids (systemic or topical; incl. 13-cis-retinoic… changes oral cancer development compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Malignant transformation (oral cancer development) · People with a diagnosis of oral leukoplakia
It is very uncertain whether topical bleomycin changes oral cancer development compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adults undergoing orthodontic treatment
Cognitive behavioural therapy (CBT) led to lower patient‐reported pain intensity or pain relief (VAS, NRS or… compared with no special instructions (control); GRADE not reported.
3 findings from 1 review
MD -27.91 [-40.10, -15.72]
1 study · 24 participants
GRADE not reported
MD -6.50 [-17.64, 4.64]
1 study · 24 participants
GRADE not reported
MD -20.67 [-32.12, -9.22]
1 study · 24 participants
Very low
Clinical resolution (oral lesion not completely resolved) · People with a diagnosis of oral leukoplakia
It is very uncertain whether topical bleomycin changes clinical resolution (oral lesion not completely resolved) compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Safety of the intervention (adverse effects) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
SoF 3, Safety of the intervention over 3 months: systemic celecoxib (1 study) - 32 intervention participants reported 56 adverse effects, 20 placebo participants reported 20; 4 grade 3 events; 2 discontinued. Ketorolac…
2 studies
GRADE not reported
Improvement of histological features (not improved) · People with a diagnosis of oral leukoplakia
The review found no eligible studies for this question.
1 finding from 1 review
Adverse effects of pain treatment · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
The review found no eligible studies for this question.
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adolescents and adults undergoing orthodontic treatment
Low‐level laser therapy (LLLT) showed no clear difference in patient‐reported pain intensity or pain relief (VAS, NRS or… compared with placebo (or no irradiation); GRADE not reported.
5 findings from 1 review
MD -10.63 [-22.33, 1.07]
2 studies · 118 participants
GRADE not reported
MD -6.39 [-8.65, -4.13]
1 study · 58 participants
GRADE not reported
Two further studies (160 participants) used bespoke assessments. Harazaki 1997 (84 participants): slightly lower proportion reporting severe pain in the intervention group, no inferential statistics. Turhani 2006 (76…
2 studies · 160 participants
GRADE not reported
Show 2 more findings
MD -10.76 [-13.80, -7.73]
2 studies · 118 participants
GRADE not reported
MD -20.27 [-24.50, -16.04]
2 studies · 118 participants
Low
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adolescents/teenagers undergoing orthodontic treatment
Experimental chewing adjuncts (bite wafers or chewing gum) showed no clear difference in patient‐reported pain intensity or pain relief (VAS, NRS or… compared with no chewing gum, placebo, or control (no adjunct); GRADE not reported.
5 findings from 1 review
MD -1.39 [-3.24, 0.64]
1 study · 39 participants
GRADE not reported
MD -29.16 [-51.67, -6.65]
1 study · 39 participants
GRADE not reported
MD -15.17 [-32.44, 2.11]
2 studies · 96 participants
GRADE not reported
Show 2 more findings
MD -15.38 [-28.90, -1.86]
2 studies · 96 participants
Very low
Non‐pharmacological interventions for alleviating pain during orthodontic treatment 2016 · Cochrane All outcomes1 day · Bite wafer subgroup (median data, opposite direction)
Otasevic 2006 (84 participants) presented median values only and reported higher median pain in the bite wafer group than the group who avoided chewing at one day (P = 0.006); data not suitable for meta‐analysis.
1 study · 84 participants
GRADE not reported
Safety of the intervention (adverse effects) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
SoF 5, Safety of the intervention up to 3 months: 'All patients in the bleomycin group developed erythema with erosion by the end of the applications, whereas erythema developed in the placebo group. Discomfort was…
1 study
GRADE not reported
Clinical resolution (oral lesion not completely resolved) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
Adverse effects of pain treatment · Adolescents and adults undergoing orthodontic treatment
The review found no eligible studies for this question.
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
1 finding from 1 review
Patient‐reported pain intensity or pain relief: VAS (1 mm to 100 mm) ‐ 24 hours. Assumed risk: Not measured. Corresponding risk: not estimable. 39 participants (1 RCT). Quality: very low. Comments: insufficient…
1 study · 39 participants
Very low
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adolescents and adults undergoing orthodontic treatment
Vibratory stimulation (vibratory adjuncts) showed no clear difference in patient‐reported pain intensity or pain relief (VAS, NRS or… compared with no vibration or placebo vibration; GRADE not reported.
5 findings from 1 review
MD 1.28 [-3.16, 5.71]
3 studies · 154 participants
GRADE not reported
MD -0.52 [-9.41, 8.36]
2 studies · 115 participants
GRADE not reported
Lobre 2015 (high risk of bias): mean overall pain intensity 8.49 mm lower on the VAS during the second month (P = 0.04) and 6.26 mm lower during the fourth month (P = 0.03); no evidence of benefit at month one or month…
2 studies
GRADE not reported
Show 2 more findings
Clinical resolution (oral lesion not completely resolved) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
SoF 4, Clinical resolution (not completely resolved) at 3 to 6 months: '3 studies (freeze-dried black raspberry gel, green tea extract capsules, mixed tea) did not find evidence of benefit.' No GRADE. Effects text:…
4 studies
GRADE not reported
Improvement of histological features (not improved) · People with a diagnosis of oral leukoplakia
Systemic beta carotene or carotenoids (incl. lycopene) may leads to lower improvement of histological features (not improved) compared with placebo or no treatment (low certainty).
1 finding from 1 review
Improvement of histological features (not improved) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
SoF 6, Histological changes: 'Not measured'. Effects text: data on histological changes from Armstrong 2013 were not available for analysis, but study authors reported no statistically significant differences in…
1 study
GRADE not reported