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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Every word you type has to appear somewhere in the question, and the closest matches are ranked first.
5,762 questions in 263 reviews · Dental caries
current versionsNo studies 321 · 5.6%Ungraded 4,450 · 77.2%Very low 455 · 7.9%Low 297 · 5.2%Moderate 200 · 3.5%High 39 · 0.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
AG + GG genotype (G-allele carriers) of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Mixed Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.69 [0.78, 3.68] | 1 study | Ungraded |
Intervention NR Microleakage/infiltration index: Er,Cr:YSGG vs traditional bur · Geraldo-Martins 2013 (excluded from meta-analysis; higher microleakage with Er,Cr:YSGG) Does Er,Cr:YSGG reduce the microleakage of restorations when used for cavity preparation? A systematic… (2020) | Qualitative NR [NR, NR] | 1 study | Ungraded |
CT genotype of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.72 [0.37, 7.92] | 3 studies | Ungraded |
Fluoride varnish applied biannually vs Fissure sealant (resin-based or glass ionomer) Caries incidence of first permanent molars (FPMs) · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures… · 2 to 3 years Comparison between Fissure Sealant and Fluoride Varnish on Caries Prevention for First Permanent Molars: a… (2020) | RR 1.29 [0.95, 1.75] | 6 studies · 6878 participants | Ungraded |
Intervention NR Marginal integrity success rate · Assessor blinding (triple-blind): Yes Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.857 [0.785, 0.908] | 16 studies | Ungraded |
Intervention NR Dental caries in permanent teeth · Children (permanent dentition) worldwide · Africa Dental caries in primary and permanent teeth in children's worldwide, 1995 to 2019: a systematic review and… (2020) | Prevalence 0.589 [0.294, 0.831] | 5 studies · 2794 participants | Ungraded |
Spectra caries detection device (Air Techniques; blue fluorescence) vs Reference standard: histology, enhanced visual examination with or without radiographs, or excavation Diagnostic accuracy (sensitivity and specificity) for detection of early enamel caries (D1 threshold) · Children or adults presenting asymptomatically or suspected of having enamel caries (in vivo/clinical studies);… · Up to 3 months between index test and reference standard (in vivo studies) Fluorescence devices for the detection of dental caries (2020) · Cochrane | The Spectra caries detection device fits into the blue fluorescence category but no studies provided data for inclusion in the meta-analysis (Markowitz 2015). | 1 study | Ungraded |
rs1126478, co-dominant model (GA genotype) vs GG or AA genotype Dental caries · Human subjects with dental caries and caries-free controls · Co-dominant model (GA vs. GG + AA) The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) | OR 0.97 [0.72, 1.32] | 4 studies · 1802 participants | Ungraded |
Intervention NR Marginal integrity success rate · Material type: High-viscosity glass ionomer cement (HVGIC) Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.743 [0.553, 0.871] | 5 studies | Ungraded |
Tooth-coloured direct restorative materials (composite, compomer, giomer, RMGIC, HVGIC, open-sandwich) vs No comparator group (single-arm pooled success rate; materials/techniques contrasted via moderator analyses) Retention success rate · Children with primary molars requiring proximal (Class II) restorations · 24 months, Use of coat: Yes Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.904 [0.474, 0.989] | 3 studies | Ungraded |
GERD/NERD vs Healthy controls Oral mucosa inflammation · Adults Laryngopharyngeal reflux, gastroesophageal reflux and dental disorders: A systematic review. (2020) | no estimate extracted | 5 studies | Ungraded |
Tooth-coloured direct restorative materials (composite, compomer, giomer, RMGIC, HVGIC, open-sandwich) vs No comparator group (single-arm pooled success rate; materials/techniques contrasted via moderator analyses) Retention success rate · Children with primary molars requiring proximal (Class II) restorations · 24 months, Material type: Resin-based material + total-etching adhesion Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.949 [0.868, 0.981] | 7 studies | Ungraded |
Tooth-coloured direct restorative materials (composite, compomer, giomer, RMGIC, HVGIC, open-sandwich) vs No comparator group (single-arm pooled success rate; materials/techniques contrasted via moderator analyses) Retention success rate · Children with primary molars requiring proximal (Class II) restorations · 24 months, Use of cavity conditioner: Yes Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.826 [0.605, 0.937] | 10 studies | Ungraded |
Intervention NR Prevalence of GERD/reflux (esophagitis or positive pH testing) · Adults with dental erosion Laryngopharyngeal reflux, gastroesophageal reflux and dental disorders: A systematic review. (2020) | Four studies reported the prevalence of GERD/reflux findings among patients with dental erosion, ranging from 64% to 75% (Bartlett 64% pathological distal reflux; Gudmundsson 75% esophagitis; Wilder-Smith 69% GERD at… | 3 studies | Ungraded |
GERD vs Healthy controls Dental caries · Adults Laryngopharyngeal reflux, gastroesophageal reflux and dental disorders: A systematic review. (2020) | no estimate extracted | 3 studies | Ungraded |
Home or in-office bleaching vs No bleaching Caries susceptibility, enamel demineralisation, erosion, or microhardness · Permanent teeth or extracted human teeth with artificial lesions · Varied or not stated Is Bleaching Effective in Managing Post-orthodontic White-spot Lesions? A Systematic Review. (2020) | no estimate extracted | 5 studies | Ungraded |
TT genotype of AMELX rs946252 vs CC + CT genotype of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Caries-free Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.73 [0.19, 2.87] | 2 studies | Ungraded |
CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Low caries Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 3.43 [1.21, 9.75] | 2 studies | Ungraded |
G allele of LTF rs1126478 vs A allele of LTF rs1126478 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Caries-free Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.98 [0.87, 1.10] | 4 studies | Ungraded |
AG + GG genotype (G-allele carriers) of ENAM rs3796704 vs AA genotype of ENAM rs3796704 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.64 [0.86, 3.14] | 4 studies · 1107 participants | Ungraded |
No additional acid etching (etch-and-rinse adhesive alone) after Er,Cr:YSGG preparation vs Prior acid etching before etch-and-rinse adhesive after Er,Cr:YSGG preparation Incidence of microleakage · Er,Cr:YSGG laser-prepared cavities restored with etch-and-rinse adhesive systems (in vitro) Does Er,Cr:YSGG reduce the microleakage of restorations when used for cavity preparation? A systematic… (2020) | RR 1.18 [0.63, 2.22] | 2 studies | Ungraded |
T allele of AMELX rs17878486 vs C allele of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Low caries Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.82 [1.06, 3.11] | 2 studies | Ungraded |
Resin-based fissure sealant plus fluoride varnish vs Fluoride varnish alone Number of visits to the dentist for repair of sealant or fluoride varnish application · Children and adolescents from the general population, younger than 20 years of age at the start of the study Pit and fissure sealants versus fluoride varnishes for preventing dental decay in the permanent teeth of… (2020) · Cochrane | The study (Splieth 2001) did not measure the number of visits to the dentist for repair of sealant or fluoride varnish application. | 0 studies | No studies |
Tooth-coloured direct restorative materials (composite, compomer, giomer, RMGIC, HVGIC, open-sandwich) vs No comparator group (single-arm pooled success rate; materials/techniques contrasted via moderator analyses) Retention success rate · Children with primary molars requiring proximal (Class II) restorations · 24 months, Trim-and-fill adjusted (publication-bias sensitivity) Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.839 [0.764, 0.893] | 34 (27 observed + 7 imputed) studies | Ungraded |
T allele of AMELX rs6639060 vs C allele of AMELX rs6639060 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.08 [0.63, 1.85] | 1 study | Ungraded |
Gastroesophageal or laryngopharyngeal reflux (GERD/LPR) vs Healthy individuals (controls) Salivary function impairment (buffering capacity, flow rate, oral pH) · Adults with GERD/LPR reflux Laryngopharyngeal reflux, gastroesophageal reflux and dental disorders: A systematic review. (2020) | Mixed/controversial salivary findings: reduced salivary buffering capacity supported in three studies (Correa, Holbrook, Filipi) with low oral pH and reduced flow as additional factors in GERD patients, but Meurman and Schroeder found no significant salivary abnormalities; no pooled estimate. | 6 studies | Ungraded |
Intervention NR Anatomic form success rate · Cavity form: Atraumatic restorative treatment (ART) Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.749 [0.606, 0.853] | 6 studies | Ungraded |
All fluorescence-based devices (red, blue, and green fluorescence combined) vs Reference standard: histology, enhanced visual examination with or without radiographs, or excavation Diagnostic odds ratio (DOR) by subgroup: Permanent/mixed dentition (detection of early enamel caries, D1 threshold) · Children or adults presenting asymptomatically or suspected of having enamel caries (in vivo/clinical studies);… · Up to 3 months between index test and reference standard (in vivo studies), Permanent/mixed dentition Fluorescence devices for the detection of dental caries (2020) · Cochrane | DOR 15.21 [11.35, 20.37] | NR | Ungraded |
TT genotype of AMELX rs17878486 vs CC + CT genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 3.55 [0.72, 17.60] | 3 studies | Ungraded |
Intervention NR Absence of recurrent caries success rate · Random assignment: No/Incorrect Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.899 [0.828, 0.943] | 15 studies | Ungraded |
Intervention NR Marginal integrity success rate · Material type: Resin-modified glass ionomer cement (RMGIC) Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.927 [0.843, 0.968] | 6 studies | Ungraded |
Younger children's age (3-5 years) vs Older children (>5 years) Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years · Age 3 years The Association of Oral Health Status, demographic characteristics and socioeconomic determinants with Oral… (2020) | OR 2.00 [1.42, 2.57] | 2 studies | Ungraded |
LTF rs1126478 AG + GG genotype vs AA genotype Dental caries susceptibility · Age group: Children (n=4) individuals with caries/high caries and controls · Age group: Children (n=4) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.99 [0.81, 1.23] | 4 studies | Ungraded |
T allele of AMELX rs6639060 vs C allele of AMELX rs6639060 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Adults Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.08 [0.63, 1.85] | 1 study | Ungraded |
G allele of ENAM rs1264848 vs A allele of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Low caries Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.03 [0.83, 1.29] | 2 studies | Ungraded |
ENAM rs3796703 T allele vs C allele Dental caries susceptibility · Ethnicity: Asian (n=2) individuals with caries/high caries and controls · Ethnicity: Asian (n=2) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.92 [0.24, 3.58] | 2 studies | Ungraded |
TT genotype of AMELX rs2106416 vs CC genotype of AMELX rs2106416 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.83 [0.47, 7.06] | 3 studies · 285 participants | Ungraded |
TT genotype of ENAM rs3796703 vs CC + CT genotype of ENAM rs3796703 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 2.90 [0.92, 9.12] | 2 studies · 1152 participants | Ungraded |
Gastroesophageal or laryngopharyngeal reflux (GERD/LPR) vs Healthy individuals (controls) Oral/pharyngeal microbiota modifications · Adults with GERD/LPR reflux Laryngopharyngeal reflux, gastroesophageal reflux and dental disorders: A systematic review. (2020) | no estimate extracted | 0 studies | No studies |
ENAM rs3796703 CT + TT genotype vs CC genotype Dental caries susceptibility · Individuals with caries/high caries and caries-free or low-caries controls · Overall (n=2) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.90 [0.23, 3.63] | 2 studies · 1152 participants | Ungraded |
Low birth weight (<2500 g) vs Normal birth weight (2500 g or more) Early childhood caries (ECC) · Children aged 6 years or younger (preschool children) · Children aged 3 years or younger Relationship between preterm, low birth weight and early childhood caries: a meta-analysis of the… (2020) | OR 0.78 [0.24, 2.51] | 3 studies | Ungraded |
AMELX rs2106416 T allele vs C allele Dental caries susceptibility · Individuals with caries/high caries and caries-free or low-caries controls · Overall (n=3) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.59 [0.16, 2.11] | 3 studies · 285 participants | Ungraded |
rs1126478 genotype distribution vs Caries-free control genotype distribution Dental caries (by severity) · Human subjects stratified by dental caries severity and caries-free controls · Moderate caries (DMFT 2 to 3); Volckova et al. 2014 The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) | OR 1.04 [0.80, 1.34] | 1 study | Ungraded |
Tooth-coloured direct restorative materials (composite, compomer, giomer, RMGIC, HVGIC, open-sandwich) vs No comparator group (single-arm pooled success rate; materials/techniques contrasted via moderator analyses) Retention success rate · Children with primary molars requiring proximal (Class II) restorations · 24 months, Cavity form: Conventional cavity design Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.936 [0.895, 0.961] | 19 studies | Ungraded |
Intervention NR Anatomic form success rate · Random assignment: Correct Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.912 [0.809, 0.962] | 10 studies | Ungraded |
Tooth-coloured direct restorative materials (composite, compomer, giomer, RMGIC, HVGIC, open-sandwich) vs No comparator group (single-arm pooled success rate; materials/techniques contrasted via moderator analyses) Retention success rate · Children with primary molars requiring proximal (Class II) restorations · 24 months, Study design: Randomized controlled trial Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.854 [0.718, 0.931] | 15 studies | Ungraded |
Laser fluorescence (DIAGNOdent and DIAGNOdent pen) vs Reference standard: histology (in vitro studies) or visual-tactile examination (in vivo studies) Specificity · Adults presenting asymptomatically or suspected of having root caries (in vivo studies); extracted teeth of adults (in… Tests to detect and inform the diagnosis of root caries (2020) · Cochrane | 4 studies (4997 root surfaces) investigated laser fluorescence and reported estimates of sensitivity ranging from 0.50 to 0.81 and specificity ranging from 0.40 to 0.80. 2 studies evaluated tests on in vivo primary… | 4 studies | Very low |
Intervention NR Marginal integrity success rate · Rubber dam isolation: No Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.899 [0.833, 0.941] | 14 studies | Ungraded |
Intervention NR Absence of recurrent caries success rate · Material type: Open sandwich restoration Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.950 [0.677, 0.994] | 1 study | Ungraded |
T allele of AMELX rs2106416 vs C allele of AMELX rs2106416 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.59 [0.16, 2.11] | 3 studies · 285 participants | Ungraded |