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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Every word you type has to appear somewhere in the question, and the closest matches are ranked first.
5,762 questions in 263 reviews · Dental caries
current versionsNo studies 321 · 5.6%Ungraded 4,450 · 77.2%Very low 455 · 7.9%Low 297 · 5.2%Moderate 200 · 3.5%High 39 · 0.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
GG genotype of LTF rs1126478 vs AA genotype of LTF rs1126478 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.03 [0.80, 1.33] | 4 studies | Ungraded |
Red fluorescence devices (DIAGNOdent, DIAGNOdent pen, MidWest; excitation wavelength >655 nm) vs Reference standard: histology, enhanced visual examination with or without radiographs, or excavation Diagnostic odds ratio (DOR) for detection of early enamel caries (D1 threshold) · Children or adults presenting asymptomatically or suspected of having enamel caries (in vivo/clinical studies);… · Up to 3 months between index test and reference standard (in vivo studies) Fluorescence devices for the detection of dental caries (2020) · Cochrane | DOR 12.75 [9.74, 16.68] | 68 studies | Ungraded |
Intervention NR Anatomic form success rate · Use of coat: Yes Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.785 [0.608, 0.896] | 5 studies | Ungraded |
Vegetarian diet (any diet excluding all meat, poultry and fish) vs Nonvegetarian diet Presence of dental erosion · General population (children and adults) assessed for dental hard-tissue health · Sensitivity analysis excluding Linkosalo & Markkanen 1985 (outlier) Vegetarian diet and its possible influence on dental health: A systematic literature review. (2020) | OR 1.97 [1.19, 3.27] | 5 studies | Ungraded |
Intervention NR Marginal integrity success rate · Use of coat: Yes Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.804 [0.595, 0.919] | 5 studies | Ungraded |
Illicit drug use vs People who do not use drugs DMFT index (dental caries experience) · People who use drugs (PWUD): methamphetamine, heroin, opiate, cannabis and cocaine users Dental caries and periodontal disease among people who use drugs: a systematic review and meta-analysis. (2020) | OR 4.11 [2.07, 8.15] | 7 studies | Ungraded |
Tooth-coloured direct restorative materials (composite, compomer, giomer, RMGIC, HVGIC, open-sandwich) vs No comparator group (single-arm pooled success rate; materials/techniques contrasted via moderator analyses) Retention success rate · Children with primary molars requiring proximal (Class II) restorations · 24 months, Assessor blinding (triple-blind): No Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.934 [0.859, 0.971] | 11 studies | Ungraded |
AMELX rs946252 TT genotype vs CC + CT genotype Dental caries susceptibility · Ethnicity: Caucasian (n=2) individuals with caries/high caries and controls · Ethnicity: Caucasian (n=2) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.73 [0.19, 2.87] | 2 studies | Ungraded |
TT genotype of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 5.12 [0.09, 278.85] | 2 studies | Ungraded |
Tooth-coloured direct restorative materials (composite, compomer, giomer, RMGIC, HVGIC, open-sandwich) vs No comparator group (single-arm pooled success rate; materials/techniques contrasted via moderator analyses) Retention success rate · Children with primary molars requiring proximal (Class II) restorations · 24 months, Material type: Resin-based material + self-etching adhesion Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.824 [0.672, 0.914] | 8 studies | Ungraded |
Intervention NR Absence of recurrent caries success rate · Cavity form: Conventional cavity design Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.932 [0.889, 0.959] | 20 studies | Ungraded |
T allele of AMELX rs17878486 vs C allele of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Caries-free Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 2.87 [0.35, 23.23] | 2 studies | Ungraded |
CT genotype of AMELX rs2106416 vs CC genotype of AMELX rs2106416 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.20 [0.65, 2.22] | 2 studies | Ungraded |
CT + TT genotype (T-allele carriers) of AMELX rs2106416 vs CC genotype of AMELX rs2106416 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.59 [0.15, 2.31] | 3 studies · 285 participants | Ungraded |
TT genotype of AMELX rs6639060 vs CC genotype of AMELX rs6639060 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.04 [0.43, 2.51] | 2 studies · 301 participants | Ungraded |
CT genotype of AMELX rs946252 vs CC genotype of AMELX rs946252 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Control group: Low caries Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.95 [0.40, 2.25] | 1 study | Ungraded |
Intervention NR Marginal integrity success rate · Study design: Nonrandomized controlled trial Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.855 [0.763, 0.914] | 11 studies | Ungraded |
GG genotype of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Mixed Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.62 [0.64, 4.09] | 1 study | Ungraded |
All fluorescence-based devices (red, blue, and green fluorescence combined) vs Reference standard: histology, enhanced visual examination with or without radiographs, or excavation Diagnostic odds ratio (DOR) by subgroup: Medium dentine-caries prevalence (15% to 34%) (detection of early enamel caries, D1 threshold) · Children or adults presenting asymptomatically or suspected of having enamel caries (in vivo/clinical studies);… · Up to 3 months between index test and reference standard (in vivo studies), Medium dentine-caries prevalence (15% to 34%) Fluorescence devices for the detection of dental caries (2020) · Cochrane | DOR 15.39 [11.07, 21.41] | NR | Ungraded |
Intervention NR Anatomic form success rate · Study design: Nonrandomized controlled trial Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.844 [0.731, 0.916] | 10 studies | Ungraded |
Intraglandular botulinum neurotoxin (BoNT) injection vs No BoNT (placebo or pre-treatment baseline) Salivary osmolality (hydration level) · Patients with drooling (sialorrhea) due to neurological disease Oral health effects of botulinum toxin treatment for drooling: a systematic review. (2020) | no estimate extracted | 0 studies | No studies |
Visual examination vs Reference standard: histology Specificity · Extracted molar teeth of adults with resin composite approximal restorations (in vitro; secondary root caries;… Tests to detect and inform the diagnosis of root caries (2020) · Cochrane | Specificity 0.38 [0.14, 0.68] | 1 study | Very low |
CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Overall Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 2.30 [0.51, 10.33] | 4 studies · 442 participants | Ungraded |
GG genotype of ENAM rs1264848 vs AA + AG genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Mixed Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.09 [0.53, 2.23] | 1 study | Ungraded |
AG genotype of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Mixed Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.73 [0.77, 3.90] | 1 study | Ungraded |
Low family income (<$70/month) vs Higher family income (>=$70/month) Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years The Association of Oral Health Status, demographic characteristics and socioeconomic determinants with Oral… (2020) | OR 1.16 [1.11, 1.21] | 4 studies | Ungraded |
All fluorescence-based devices (red, blue, and green fluorescence combined) vs Reference standard: histology, enhanced visual examination with or without radiographs, or excavation Diagnostic odds ratio (DOR) by subgroup: Histology or excavation reference standard (detection of early enamel caries, D1 threshold) · Children or adults presenting asymptomatically or suspected of having enamel caries (in vivo/clinical studies);… · Up to 3 months between index test and reference standard (in vivo studies), Histology or excavation reference standard Fluorescence devices for the detection of dental caries (2020) · Cochrane | DOR 13.49 [10.25, 17.76] | NR | Ungraded |
GG genotype of ENAM rs3796704 vs AA genotype of ENAM rs3796704 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Children Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.61 [0.13, 2.93] | 2 studies | Ungraded |
AMELX rs17878486 T allele vs C allele Dental caries susceptibility · Ethnicity: Asian (n=1) individuals with caries/high caries and controls · Ethnicity: Asian (n=1) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.38 [0.25, 7.75] | 1 study | Ungraded |
Tooth-coloured direct restorative materials (composite, compomer, giomer, RMGIC, HVGIC, open-sandwich) vs No comparator group (single-arm pooled success rate; materials/techniques contrasted via moderator analyses) Retention success rate · Children with primary molars requiring proximal (Class II) restorations · 24 months, Dentist experience: Non-experienced Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.554 [0.168, 0.885] | 2 studies | Ungraded |
TT genotype of AMELX rs17878486 vs CC + CT genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Age group: Adults Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.89 [0.30, 11.85] | 1 study | Ungraded |
AMELX rs2106416 CT genotype vs CC genotype Dental caries susceptibility · Individuals with caries/high caries and caries-free or low-caries controls · Overall (n=3) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.55 [0.13, 2.25] | 3 studies · 285 participants | Ungraded |
Tooth-coloured direct restorative materials (composite, compomer, giomer, RMGIC, HVGIC, open-sandwich) vs No comparator group (single-arm pooled success rate; materials/techniques contrasted via moderator analyses) Retention success rate · Children with primary molars requiring proximal (Class II) restorations · 24 months, Cavity form: Atraumatic restorative treatment (ART) Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.649 [0.488, 0.783] | 8 studies | Ungraded |
Intraglandular botulinum neurotoxin (BoNT) injection vs No BoNT (placebo or pre-treatment baseline) Salivary Streptococcus mutans counts · Patients with drooling (sialorrhea) due to neurological disease · Before vs after BoNT injection Oral health effects of botulinum toxin treatment for drooling: a systematic review. (2020) | The RCT by Wu et al. reported no statistically significant changes in S. mutans CFU counts (p-values only). The studies of Tiigimae-Saar did not find statistically significant differences in S. mutans CFU counts either. | 3 studies | Ungraded |
Intervention NR Absence of recurrent caries success rate · Study design: Randomized controlled trial Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.913 [0.849, 0.951] | 15 studies | Ungraded |
Intervention NR Absence of recurrent caries success rate · Material type: Resin-based material + total-etching adhesion Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.894 [0.771, 0.954] | 7 studies | Ungraded |
LTF rs1126478 GG genotype vs AA + AG genotype Dental caries susceptibility · Age group: Children (n=4) individuals with caries/high caries and controls · Age group: Children (n=4) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.95 [0.80, 1.13] | 4 studies | Ungraded |
Multiple LTF gene variants (joint / gene-based) vs Caries-free controls Dental caries · Human subjects with dental caries and caries-free controls · Gene-based joint association (LTF) The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) | P-value (gene-based, weighted TPM) 0.0007 | NR | Ungraded |
Tooth-coloured direct restorative materials (composite, compomer, giomer, RMGIC, HVGIC, open-sandwich) vs No comparator group (single-arm pooled success rate; materials/techniques contrasted via moderator analyses) Retention success rate · Children with primary molars requiring proximal (Class II) restorations · 24 months, Material type: Open sandwich restoration Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.950 [0.639, 0.995] | 1 study | Ungraded |
GG genotype of ENAM rs3796704 vs AA + AG genotype of ENAM rs3796704 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Mixed Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.43 [0.67, 3.05] | 1 study | Ungraded |
AG + GG genotype (G-allele carriers) of LTF rs1126478 vs AA genotype of LTF rs1126478 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Asian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.02 [0.78, 1.33] | 2 studies | Ungraded |
TT genotype of AMELX rs2106416 vs CC + CT genotype of AMELX rs2106416 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Ethnicity: Caucasian Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.67 [0.44, 6.34] | 2 studies | Ungraded |
Tooth-coloured direct restorative materials (composite, compomer, giomer, RMGIC, HVGIC, open-sandwich) vs No comparator group (single-arm pooled success rate; materials/techniques contrasted via moderator analyses) Retention success rate · Children with primary molars requiring proximal (Class II) restorations · 24 months Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.879 [0.803, 0.928] | 27 studies | Ungraded |
AMELX rs17878486 CT + TT genotype vs CC genotype Dental caries susceptibility · Ethnicity: Caucasian (n=2) individuals with caries/high caries and controls · Ethnicity: Caucasian (n=2) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 2.03 [0.10, 42.44] | 2 studies | Ungraded |
AMELX rs6639060 CT genotype vs CC genotype Dental caries susceptibility · Ethnicity: Caucasian (n=1) individuals with caries/high caries and controls · Ethnicity: Caucasian (n=1) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 1.27 [0.49, 3.30] | 1 study | Ungraded |
ENAM rs3796703 CT genotype vs CC genotype Dental caries susceptibility · Ethnicity: Asian (n=2) individuals with caries/high caries and controls · Ethnicity: Asian (n=2) Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) | OR 0.89 [0.23, 3.48] | 2 studies | Ungraded |
Vegetarian diet (any diet excluding all meat, poultry and fish) vs Nonvegetarian diet Number of natural teeth (missing/present teeth, edentulousness, MT component of DMFT) · General population (children and adults) assessed for dental hard-tissue health Vegetarian diet and its possible influence on dental health: A systematic literature review. (2020) | Seven studies reported on the number of teeth with conflicting findings; meta-analysis was not possible due to inconsistent outcome definitions. One study found vegetarians had significantly more teeth; two found no… | 7 studies | Ungraded |
Tooth bleaching (carbamide or hydrogen peroxide; home or in-office) vs No bleaching (untreated or pH-cycling control) Enamel demineralisation and susceptibility to caries or acid erosion (microhardness, mineral loss) · Permanent teeth / enamel specimens (in vitro) Is Bleaching Effective in Managing Post-orthodontic White-spot Lesions? A Systematic Review. (2020) | Four studies at high risk of bias and one study at moderate risk reached the overall conclusion that neither home- nor in-office bleaching of permanent teeth was associated with an increased susceptibility to… | 5 studies | Ungraded |
Tooth-coloured direct restorative materials (composite, compomer, giomer, RMGIC, HVGIC, open-sandwich) vs No comparator group (single-arm pooled success rate; materials/techniques contrasted via moderator analyses) Retention success rate · Children with primary molars requiring proximal (Class II) restorations · 24 months, Reporting bias: Yes Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. (2020) | Proportion 0.935 [0.726, 0.987] | 3 studies | Ungraded |
Intervention NR Dental caries in primary teeth · Children (primary dentition) worldwide · Australia Dental caries in primary and permanent teeth in children's worldwide, 1995 to 2019: a systematic review and… (2020) | Prevalence 0.285 [0.203, 0.385] | 3 studies · 6472 participants | Ungraded |