What do systematic reviews say?

Comparison 9: NaSSAs vs placebo

Comparison 4: NaSSAs may leads to lower treatment efficacy ‐ Treatment response, as measured by the Global… compared with placebo (low certainty).

• Pharmacotherapy for post traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
  RR 0.45 [0.22, 0.94]
  1 study · 26 participants
  Low

Comparison 12: SNRIs vs placebo

The review found no eligible studies for this question.

• Pharmacotherapy for post traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Self‐management interventions vs usual care

• Self‐management interventions for people with chronic obstructive pulmonary disease 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1647 participants
  Moderate

Pharmaceutical interventions vs placebo

• Pharmaceutical interventions for emotionalism after stroke 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 72 participants
  Very low

CR oxycodone vs CR morphine

• Oxycodone for cancer‐related pain 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 23 participants
  Very low

CR oxycodone vs IR oxycodone

The review found no eligible studies for this question.

• Oxycodone for cancer‐related pain 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings table ‐ Aspiration/flush vs aspiration

Summary of findings table ‐ Aspiration/flush showed no clear difference in clinical pregnancy rate per woman randomised compared with aspiration (low certainty).

• Follicular flushing during oocyte retrieval in assisted reproductive techniques 2022 · Cochrane Headline outcomes only
  OR 1.13 [0.85, 1.51]
  7 studies · 939 participants
  Low

Any glucocorticoid vs no glucocorticoids or placebo

It is very uncertain whether glucocorticoids changes incidence of ectopic pregnancies per couple compared with no glucocorticoids or placebo (very low certainty).

• Peri‐implantation glucocorticoid administration for assisted reproductive technology cycles 2022 · Cochrane Headline outcomes only
  OR 2.28 [0.33, 15.62]
  3 studies · 320 participants
  Very low

Any glucocorticoid vs no glucocorticoids or placebo

It is very uncertain whether glucocorticoids changes incidence of multiple pregnancies per couple compared with no glucocorticoids or placebo (very low certainty).

• Peri‐implantation glucocorticoid administration for assisted reproductive technology cycles 2022 · Cochrane Headline outcomes only
  OR 0.86 [0.33, 2.2]
  4 studies · 504 participants
  Very low

Any glucocorticoid vs no glucocorticoids or placebo

It is very uncertain whether glucocorticoids changes ongoing pregnancy rate per couple compared with no glucocorticoids or placebo (very low certainty).

• Peri‐implantation glucocorticoid administration for assisted reproductive technology cycles 2022 · Cochrane Headline outcomes only
  OR 1.19 [0.8, 1.76]
  3 studies · 476 participants
  Very low

Any glucocorticoid vs no glucocorticoids or placebo

Glucocorticoids showed no clear difference in clinical pregnancy rate per couple –pregnancy rate per couple… compared with no glucocorticoids or placebo (low certainty).

• Peri‐implantation glucocorticoid administration for assisted reproductive technology cycles 2022 · Cochrane Headline outcomes only
  OR 1.17 [0.95, 1.44]
  13 studies · 1967 participants
  Low
• Peri‐implantation glucocorticoid administration for assisted reproductive technology cycles 2022 · Cochrane Headline outcomes only
  OR 1.2 [0.87, 1.67]
  6 studies · 780 participants
  Very low
• Peri‐implantation glucocorticoid administration for assisted reproductive technology cycles 2022 · Cochrane Headline outcomes only
  OR 1.15 [0.87, 1.5]
  7 studies · 1187 participants
  Very low

Any glucocorticoid vs no glucocorticoids or placebo

It is very uncertain whether glucocorticoids changes clinical pregnancy rate per couple – subgroup IVF compared with no glucocorticoids or placebo (very low certainty).

• Peri‐implantation glucocorticoid administration for assisted reproductive technology cycles 2022 · Cochrane Headline outcomes only
  OR 1.44 [1, 2.08]
  5 studies · 724 participants
  Very low

Any glucocorticoid vs no glucocorticoids or placebo

It is very uncertain whether glucocorticoids changes clinical pregnancy rate per couple – subgroup ICSI compared with no glucocorticoids or placebo (very low certainty).

• Peri‐implantation glucocorticoid administration for assisted reproductive technology cycles 2022 · Cochrane Headline outcomes only
  OR 1.08 [0.81, 1.42]
  6 studies · 992 participants
  Very low

Interventions for involving patients in decision‐making about their health care vs usual care

• Shared decision‐making interventions for people with mental health conditions 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 53 participants
  Very low

Interventions for involving patients in decision‐making about their health care vs usual care

• Shared decision‐making interventions for people with mental health conditions 2022 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 717 participants
  Low

Interventions for involving patients in decision‐making about their health care vs usual care

• Shared decision‐making interventions for people with mental health conditions 2022 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 898 participants
  Low

Antioxidants vs placebo or no treatment

Antioxidants may leads to higher clinical pregnancy rate per couple randomised compared with placebo or no treatment (low certainty).

• Antioxidants for male subfertility 2022 · Cochrane Headline outcomes only
  OR 1.89 [1.45, 2.47]
  20 studies · 1706 participants
  Low

Intratympanic corticosteroids vs systemic corticosteroids

Intratympanic corticosteroids showed no clear difference in change in hearing threshold determined by PTA Range 0 dB to 140 dB… compared with systemic corticosteroids (low certainty).

• Intratympanic corticosteroids for sudden sensorineural hearing loss 2022 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 701 participants
  Low

Intratympanic plus systemic corticosteroids (combined therapy) vs systemic corticosteroids alone

Intratympanic plus systemic corticosteroids (combined therapy) showed no clear difference in change in hearing threshold determined by PTA Range 0 dB to 140 dB… compared with systemic corticosteroids alone (low certainty).

• Intratympanic corticosteroids for sudden sensorineural hearing loss 2022 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 435 participants
  Low

Intratympanic plus systemic corticosteroids (combined therapy) vs systemic corticosteroids alone

It is very uncertain whether intratympanic plus systemic corticosteroids (combined therapy) changes final hearing threshold determined by PTA A lower value represents… compared with systemic corticosteroids alone (very low certainty).

• Intratympanic corticosteroids for sudden sensorineural hearing loss 2022 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 194 participants
  Very low