Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

150 questions · 151 findings · 21 reviews

No studies found 23 · 15.2%GRADE not reported 19 · 12.6%Very low 32 · 21.2%Low 35 · 23.2%Moderate 28 · 18.5%High 14 · 9.3%

Statins vs placebo

Mean pressure gradient (mmHg) Better indicated by lower scores. · patients with aortic valve stenosis

Statin showed no clear difference in mean pressure gradient (mmHg) Better indicated by lower scores. compared with placebo (low certainty).

1 finding from 1 review

Statins vs placebo

Valve area (cm2) Better indicated by higher scores. · patients with aortic valve stenosis

Statin showed no clear difference in valve area (cm2) Better indicated by higher scores. compared with placebo (low certainty).

1 finding from 1 review

Statins vs placebo

Aortic jet velocity (m/s) · patients with aortic valve stenosis

Statin showed no clear difference in aortic jet velocity (m/s) compared with placebo (low certainty).

1 finding from 1 review

Statins vs placebo

Freedom from valve replacement · patients with aortic valve stenosis

Statin showed no clear difference in freedom from valve replacement compared with placebo (moderate certainty).

1 finding from 1 review

Statins vs placebo

All cardiovascular death · patients with aortic valve stenosis

Statin showed no clear difference in death from cardiovascular cause compared with placebo (low certainty).

1 finding from 1 review

Statins vs placebo

Hospitalisation for any reason · patients with aortic valve stenosis

It is very uncertain whether statin changes hospitalisation for any reason compared with placebo (very low certainty).

1 finding from 1 review

Statins vs placebo

Adverse events ‐ Muscle pain · patients with aortic valve stenosis

Statin showed no clear difference in adverse events ‐ Muscle pain compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Major cardiovascular events · adults with chronic kidney disease

The intervention showed no clear difference in major cardiovascular events (low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality · adults with chronic kidney disease

The intervention showed no clear difference in all‐cause mortality (low certainty).

1 finding from 1 review

Intervention not reported

Cardiovascular mortality · adults with chronic kidney disease

The intervention showed no clear difference in cardiovascular mortality (low certainty).

1 finding from 1 review