Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

163 questions · 197 findings · 15 reviews · Oral Health

No studies found 36 · 18.3%GRADE not reported 111 · 56.3%Very low 34 · 17.3%Low 6 · 3%Moderate 10 · 5.1%High 0 · 0%

38% SDF (indirect pulp capping) vs Resin-modified glass ionomer cement (RMGIC)

Restoration color, marginal staining and luster (esthetics) · Children with deep occlusal caries in young permanent first molars (indirect pulp capping)

RMGIC gave significantly better restoration esthetics than SDF, which caused black staining (p=0.03; ungraded).

1 finding from 1 review

38% silver diamine fluoride vs Atraumatic restorative treatment (ART)

Caries/restoration status in permanent molars · Children with dental caries in permanent (first) molars

SDF gave significantly better caries/restoration outcomes than ART over 9 months in children's permanent molars (p=0.004; ungraded).

1 finding from 1 review

38% SDF plus oral health education vs oral health instruction plus tonic water

new root-surface carious lesions or restorations · community-dwelling older adults with root caries

SDF had a 62% preventative fraction; no pooled estimate or GRADE rating was reported.

1 finding from 1 review

Sodium fluoride (5% NaF, one-time [Mauro] or every 6 months [Liu]) vs Control (water or unspecified)

New coronal caries in permanent molars (caries prevention) · Children with dental caries in permanent (first) molars

NaF gave a 48% prevented fraction (fissure site) vs water (p<0.002; ungraded).

3 findings from 1 review

38% SDF plus potassium iodide and oral health instruction vs oral health instruction plus tonic water

new root-surface carious lesions or restorations · community-dwelling older adults with root caries

SDF plus potassium iodide had a 52% preventative fraction; no pooled estimate or GRADE rating was reported.

1 finding from 1 review

Atraumatic restorative treatment (ART) sealant (one-time) vs no treatment

New coronal caries in permanent first molars (caries prevention) · Children with dental caries in permanent (first) molars

ART within a brushing programme significantly reduced caries vs control (p<0.01; ungraded).

2 findings from 1 review

2.26% ammonium bifluoride (one-time) vs Control (details reported as unavailable)

New coronal caries in permanent first molars (caries prevention) · Children with dental caries in permanent (first) molars

One-time ammonium bifluoride gave a 56% prevented fraction, similar to SDF (57%) (single study; ungraded).

1 finding from 1 review

38% SDF (one-time application) vs inactive control

New coronal carious lesions or fillings on permanent (first) molars (caries prevention) · Children with dental caries in permanent (first) molars

One-time SDF within a brushing programme did not significantly reduce caries vs control (p>0.05; ungraded).

2 findings from 1 review

38% SDF (indirect pulp capping) vs Resin-modified glass ionomer cement (RMGIC)

Secondary prevention of caries · children with deep occlusal carious lesions in permanent molars

No significant difference in secondary caries prevention was reported; no effect estimate or GRADE rating was reported.

1 finding from 1 review

38% SDF (indirect pulp capping under resin composite) vs Resin-modified glass ionomer cement (RMGIC)

Secondary caries prevention in young permanent first molars · Children with deep occlusal caries in young permanent first molars (indirect pulp capping)

SDF and RMGIC did not differ significantly for secondary caries prevention in young permanent molars (no events; p>0.05; ungraded).

1 finding from 1 review

38% SDF plus potassium iodide (KI) (indirect pulp capping) vs Resin-modified glass ionomer cement (RMGIC)

Secondary prevention of caries · children with deep occlusal carious lesions in permanent molars

No significant difference in secondary caries prevention was reported; no effect estimate or GRADE rating was reported.

1 finding from 1 review

38% SDF plus potassium iodide (KI) (indirect pulp capping) vs Resin-modified glass ionomer cement (RMGIC)

Secondary caries prevention in young permanent first molars · Children with deep occlusal caries in young permanent first molars (indirect pulp capping)

SDF+KI and RMGIC did not differ significantly for secondary caries prevention (p>0.05; ungraded).

1 finding from 1 review

SDF plus potassium iodide vs Split into two contrasts: (1) TCS paste (arrest 100%); (2) CPP-ACP (arrest 100%); SDF+KI arrest 54.8% at 24 months, p<.001

Caries arrest · Patients with early enamel carious lesions on permanent molars

SDF plus potassium iodide arrested 54.8% of early enamel lesions at 24 months; no pooled estimate or GRADE rating was reported.

1 finding from 1 review

38% SDF + potassium iodide solution (applied annually) vs Tricalcium silicate (TCS) paste (applied twice daily)

Remineralization/arrest of early enamel carious lesions · Patients with early enamel carious lesions on permanent molars

For early enamel lesions, annual SDF+KI was significantly LESS effective than twice-daily tricalcium silicate paste (54.8% vs 100% arrested; p<0.001; ungraded).

1 finding from 1 review

Resin sealant (one-time) vs Control (water)

New coronal caries in permanent molars (caries prevention) · Children with dental caries in permanent (first) molars

Resin sealant gave a 65% prevented fraction (fissure site) vs water, the highest fissure-site value (p<0.002; ungraded).

2 findings from 1 review

38% silver diamine fluoride vs Glass ionomer cement (GIC) plus fluoride varnish

Caries prevention (preventive fraction, SDF vs GIC+5% fluoride varnish) · intellectually disabled individuals with caries in permanent posterior teeth

SDF had a 45% preventative fraction versus glass ionomer cement plus fluoride varnish; no pooled estimate or GRADE rating was reported.

1 finding from 1 review

38% SDF plus oral health education vs oral health instruction plus water

new root-surface carious lesions or restorations · community-dwelling older adults with root caries

SDF plus oral health education had a 33% preventative fraction at 24 months; no pooled estimate or GRADE rating was reported.

1 finding from 1 review