Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

226 questions · 228 findings · 28 reviews · Musculoskeletal

No studies found 73 · 32%GRADE not reported 6 · 2.6%Very low 37 · 16.2%Low 70 · 30.7%Moderate 22 · 9.6%High 20 · 8.8%

Intervention not reported

Participant global assessment of success (People perceived their pain as better) · people with osteoporotic vertebral compression fracture

The intervention showed no clear difference in participant global assessment of success (People perceived their… (moderate certainty).

1 finding from 1 review

Intervention not reported

Incident symptomatic vertebral fractures · people with osteoporotic vertebral compression fracture

The intervention showed no clear difference in incident symptomatic vertebral fractures (low certainty).

1 finding from 1 review

Intervention not reported

Other serious adverse events · people with osteoporotic vertebral compression fracture

The intervention showed no clear difference in other serious adverse events (low certainty).

1 finding from 1 review

Cyclophosphamide vs methylprednisolone

Response to treatment (20% improvement)* · patients with neuropsychiatric involvement in systemic lupus erythematosus

It is very uncertain whether cyclophosphamide changes response to treatment (20% improvement)* compared with methylprednisolone (very low certainty).

1 finding from 1 review

Cyclophosphamide vs methylprednisolone

Urinary tract infection · patients with neuropsychiatric involvement in systemic lupus erythematosus

It is very uncertain whether cyclophosphamide changes adverse events ‐ Urinary tract infections compared with methylprednisolone (very low certainty).

1 finding from 1 review

Cyclophosphamide vs methylprednisolone

Adverse events ‐ Death · patients with neuropsychiatric involvement in systemic lupus erythematosus

It is very uncertain whether cyclophosphamide changes adverse events ‐ Death compared with methylprednisolone (very low certainty).

1 finding from 1 review

Intervention not reported

Total number of fractures radiographs · preventing and treating osteoporosis in postmenopausal women

The intervention showed no clear difference in total number of fractures radiographs (high certainty).

1 finding from 1 review