Cochrane · systematic review · CD002265
Cyclophosphamide versus methylprednisolone for treating neuropsychiatric involvement in systemic lupus erythematosus
Fernandes Moça Trevisani, V, Castro, AA, Ferreira Neves Neto, J, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
MusculoskeletalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 7 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Cyclophosphamide versus methylprednisolone for treating neuropsychiatric involvement in systemic lupus erythematosus
Population: patients with neuropsychiatric involvement in systemic lupus erythematosus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Response to treatment (20% improvement)* Cyclophosphamide vs methylprednisolone | RR 2.05 [1.13, 3.73] | 1 study · 32 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events ‐ Urinary tract infections Cyclophosphamide vs methylprednisolone | RR 0.86 [0.47, 1.57] | 1 study · 32 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events ‐ Death Cyclophosphamide vs methylprednisolone | RR 0.23 [0.03, 1.96] | 1 study · 32 participants | Very low Downgraded: risk of bias, imprecision |
SLICC scores (damage index) Scale: from 0 to 48 (lower is better) Cyclophosphamide vs methylprednisolone | no estimate extracted | 1 study · 32 participants | Very low Downgraded: risk of bias, imprecision |
SLEDAI scores (disease activity index) Scale: from 0 to 106 (lower is better) Cyclophosphamide vs methylprednisolone | no estimate extracted | 1 study · 32 participants | Very low Downgraded: risk of bias, imprecision |
Prednisone sparing Cyclophosphamide vs methylprednisolone | no estimate extracted | 1 study · 32 participants | Very low Downgraded: risk of bias, imprecision |
Seizures Cyclophosphamide vs methylprednisolone | RR 2.57 [0.92, 7.14] | 1 study · 11 participants | Very low Downgraded: risk of bias, imprecision |