Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,061 questions · 2,151 findings · 116 reviews

No studies found 609 · 28.3%GRADE not reported 268 · 12.5%Very low 635 · 29.5%Low 491 · 22.8%Moderate 122 · 5.7%High 26 · 1.2%

Pharmacological interventions vs placebo

Incidence of depression ‐ short‐term: < 6 months · adults with long‐term physical conditions (18 years or older)

It is very uncertain whether pharmacological interventions changes incidence of depression ‐ short‐term: < 6 months compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological interventions vs placebo

Incidence of depression ‐ medium term: 6‐12 months · adults with long‐term physical conditions (18 years or older)

It is very uncertain whether pharmacological interventions changes incidence of depression ‐ medium‐term: 6‐12 months compared with placebo (very low certainty).

1 finding from 1 review

Light interventions (1/7): Bright light at night vs normal light (300 lux)

Sleepiness during the night shift, postintervention; · Shift workers
4 findings from 1 review
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Nap interventions (1/2): Nap at night (single nap opportunity) vs no‐nap

Sleepiness during the night shift, postintervention; · Shift workers
5 findings from 1 review
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Pregabalin vs placebo

Treatment‐related adverse effects · adults and children with sickle cell disease experiencing neuropathic pain

It is very uncertain whether summary of findings ‐ Pharmacological intervention (pregabalin) changes treatment‐related adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Non‐pharmacological interventions for fear of childbirth (tocophobia) vs usual care

Birth preferences: prefer caesarean section · women with fear of childbirth (tocophobia)

Non‐pharmacological interventions for fear of childbirth (tocophobia) showed no clear difference in birth preferences: prefer caesarean section compared with usual care (low certainty).

1 finding from 1 review