Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

493 questions · 509 findings · 56 reviews · Headline outcomes only

No studies found 149 · 29.3%GRADE not reported 9 · 1.8%Very low 128 · 25.1%Low 123 · 24.2%Moderate 79 · 15.5%High 21 · 4.1%

Heliox vs placebo or no treatment

Proportion of children re‐presenting for medical care for ongoing croup symptoms (return to care) · children with croup

Heliox showed no clear difference in proportion of children re‐presenting for medical care for ongoing… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Cognitive behavioural therapy as vs standard‐of‐care therapy

Reduction in physical signs Decrease in seizure frequency End of treatment · people with conversion disorder according to DSM‐IV or ICD‐10 criteria

It is very uncertain whether cognitive behavioural therapy as changes reduction in physical signs Reduction in monthly seizure frequency… compared with standard medical care (very low certainty).

2 findings from 1 review

Cognitive behavioural therapy as vs standard‐of‐care therapy

Reduction in physical sign Seizure freedom as assessed by a daily self‐reported seizure diary End of treatment · people with conversion disorder according to DSM‐IV or ICD‐10 criteria

It is very uncertain whether cognitive behavioural therapy as changes reduction in physical sign Seizure freedom as assessed by a daily… compared with standard medical care (very low certainty).

1 finding from 1 review

Acyclovir vs placebo, vitamins, or no treatment

The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by a medical practitioner · pityriasis rosea

Acyclovir probably leads to higher the proportion of participants with good or excellent rash… compared with placebo, vitamins, or no treatment (moderate certainty).

1 finding from 1 review

Intervention not reported

The rate of resolution of MBO with medical management only in patients receiving OWSC compared with those not receiving it (therapeutic). · Adults 18 yrs and over with malignant bowel obstruction (MBO) as defined by the International Conference on MBO, with no indication for…

The review found no eligible studies for this question.

1 finding from 1 review

Tranexamic acid vs placebo/no treatment

Use of additional medical interventions to control PPH · pregnant women undergoing vaginal or caesarean birth who received TA for the prevention of postpartum haemorrhage

Tranexamic acid probably leads to lower use of additional medical interventions to control PPH compared with placebo/no treatment (moderate certainty).

1 finding from 1 review

Systemic aminocaproic acid vs placebo

Short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment · people with traumatic hyphema

Systemic aminocaproic acid showed no clear difference in short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment compared with placebo (low certainty).

1 finding from 1 review

Systemic tranexamic acid vs control

Short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment · people with traumatic hyphema

Systemic tranexamic acid showed no clear difference in short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment compared with control (moderate certainty).

1 finding from 1 review

Systemic aminocaproic acid vs placebo

Long‐term visual acuity 20/40 or better > 2 months after treatment · people with traumatic hyphema

Systemic aminocaproic acid showed no clear difference in long‐term visual acuity 20/40 or better > 2 months after treatment compared with placebo (low certainty).

1 finding from 1 review

Non‐pharmaceutical interventions vs control

Visual acuity · people with traumatic hyphema

Non‐pharmaceutical interventions showed no clear difference in short‐term visual acuity between 20/20 and 20/60 at end of… compared with control (low certainty).

2 findings from 1 review

Non‐pharmaceutical interventions vs control

Risk of secondary hemorrhage; ambulatory treatment versus bed rest · people with traumatic hyphema

Non‐pharmaceutical interventions showed no clear difference in risk of secondary hemorrhage; ambulatory treatment vs bed rest compared with control (low certainty).

1 finding from 1 review

Topical aminocaproic acid vs placebo

Short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment · people with traumatic hyphema

Topical aminocaproic acid showed no clear difference in short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment compared with placebo (low certainty).

1 finding from 1 review