Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,640 questions · 2,709 findings · 446 reviews

No studies found 593 · 21.9%GRADE not reported 241 · 8.9%Very low 538 · 19.9%Low 706 · 26.1%Moderate 516 · 19%High 115 · 4.2%

Long‐acting beta2‐agonist plus tiotropium vs tiotropium

Hospital admissions · addition to tiotropium versus either tiotropium or LABA alone for chronic obstructive pulmonary disease

Long‐acting beta2‐agonist plus tiotropium showed no clear difference in hospital admission (all cause) compared with tiotropium alone (moderate certainty).

1 finding from 1 review

Long‐acting beta2‐agonist plus tiotropium vs tiotropium

Hospital admission (exacerbation) · addition to tiotropium versus either tiotropium or LABA alone for chronic obstructive pulmonary disease

Long‐acting beta2‐agonist plus tiotropium showed no clear difference in hospital admission (exacerbation) compared with tiotropium alone (low certainty).

1 finding from 1 review

Long‐acting beta2‐agonist plus tiotropium vs tiotropium

Mortality (all cause) · addition to tiotropium versus either tiotropium or LABA alone for chronic obstructive pulmonary disease

Long‐acting beta2‐agonist plus tiotropium showed no clear difference in mortality (all cause) compared with tiotropium alone (low certainty).

1 finding from 1 review

Supervised dosing with a long‐acting medication vs unsupervised consumption

Retention [ · patients with opioid dependence

Supervised dosing with a long‐acting medication showed no clear difference in retention ‐ retention at the end of treatment (number of participants) compared with unsupervised consumption (low certainty).

2 findings from 1 review

Supervised dosing with a long‐acting medication vs unsupervised consumption

Adverse serious events (any) (number of participants) · patients with opioid dependence

It is very uncertain whether supervised dosing with a long‐acting medication changes adverse serious events (any) (number of participants) compared with unsupervised consumption (very low certainty).

1 finding from 1 review

Long‐stored ('older') PRBC (≥ 21 days of storage) vs short‐stored (fresh) PRBC (< 21 days of storage)

Death from any cause · patients requiring blood transfusion (children with malaria and adults with a traumatic injury)

It is very uncertain whether long‐stored ('older') PRBC (≥ 21 days of storage) changes death from any cause compared with short‐stored (fresh) PRBC (< 21 days of storage) (very low certainty).

1 finding from 1 review

Long‐stored ('older') PRBC (≥ 21 days of storage) vs short‐stored (fresh) PRBC (< 21 days of storage)

Transfusion‐related acute lung injury ‐ not measured · patients requiring blood transfusion (children with malaria and adults with a traumatic injury)

The review found no eligible studies for this question.

1 finding from 1 review