Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

227 questions · 258 findings · 32 reviews

No studies found 68 · 26.4%GRADE not reported 32 · 12.4%Very low 47 · 18.2%Low 70 · 27.1%Moderate 34 · 13.2%High 7 · 2.7%

Summary of findings: high‐dose urate oxidase vs low‐dose urate oxidase

Serum urate normalisation ‐ not reported · children with haematological malignancy at risk of tumour lysis syndrome

Summary of findings: high‐dose urate oxidase showed no clear difference in normalisation of serum uric acid ( compared with low‐dose urate oxidase (low certainty).

1 finding from 1 review

Summary of findings: high‐dose urate oxidase vs low‐dose urate oxidase

Frequency of adverse events ( · children with haematological malignancy at risk of tumour lysis syndrome

Summary of findings: high‐dose urate oxidase showed no clear difference in frequency of adverse events ( compared with low‐dose urate oxidase (low certainty).

1 finding from 1 review