Salivary flow rate (stimulated) · Patients with anorexia nervosa aged >=12 years (mean age ~18.4; entirely female in reported data), general community-dwelling population
Stimulated salivary flow rate was significantly lower in anorexia nervosa patients than controls, but only unstimulated flow was meta-analyzed; this outcome is ungraded.
1 finding from 1 review
Salivary pH · Patients with anorexia nervosa aged >=12 years (mean age ~18.4; entirely female in reported data), general community-dwelling population
Anorexia nervosa is associated with significantly lower salivary pH than healthy controls (MD -0.39, 95% CI -0.54 to -0.24; low certainty).
1 finding from 1 review
Salivary alpha-amylase · Patients with anorexia nervosa aged >=12 years (mean age ~18.4; entirely female in reported data), general community-dwelling population
There is no significant difference in salivary alpha-amylase between anorexia nervosa patients and healthy controls (MD 6.32 U/l, 95% CI -6.14 to 18.79; low certainty).
1 finding from 1 review
Salivary flow rate (unstimulated) · Patients with anorexia nervosa aged >=12 years (mean age ~18.4; entirely female in reported data), general community-dwelling population
Anorexia nervosa probably reduces unstimulated salivary flow rate versus healthy controls (MD -0.27 ml/min, 95% CI -0.31 to -0.24; moderate certainty).
1 finding from 1 review
Gingival (marginal) recession · Patients with anorexia nervosa aged >=12 years (mean age ~18.4; entirely female in reported data), general community-dwelling population
Gingival (marginal) recession was significantly higher in anorexia nervosa patients than controls in both reporting studies, but was not pooled or graded (ungraded).
1 finding from 1 review
Dental erosion · Patients with anorexia nervosa aged >=12 years (mean age ~18.4; entirely female in reported data), general community-dwelling population
Dental erosion was more prevalent in anorexia nervosa patients than controls (low erosive-wear severity), but was not pooled or graded (ungraded).
1 finding from 1 review
Plaque · Patients with anorexia nervosa aged >=12 years (mean age ~18.4; entirely female in reported data), general community-dwelling population
Anorexia nervosa patients tended to have higher plaque accumulation than healthy controls (significant in 2 of 3 studies), but results were not pooled or graded (ungraded).
1 finding from 1 review
Caries experience · Patients with anorexia nervosa aged >=12 years (mean age ~18.4; entirely female in reported data), general community-dwelling population
Anorexia nervosa is associated with significantly higher caries experience (DMFT) than healthy controls (MD 2.00 teeth, 95% CI 0.87 to 3.13; low certainty).
1 finding from 1 review
Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility
It is very uncertain whether exposure to clomiphene citrate and gonadotropins for subfertility changes endometrial cancer compared with untreated subfertile women and endometrial cancer risk (very low certainty).
1 finding from 1 review
Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility
It is very uncertain whether exposure to clomiphene citrate and gonadotropins for subfertility changes endometrial cancer compared with general population and endometrial cancer risk (very low certainty).
1 finding from 1 review
Oral health-related quality of life · Adolescents (10-19 years)
The umbrella review reported a greater negative oral health-related quality-of-life impact for traumatic injuries involving pulp exposure or tooth darkening.
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Incidence of new ICLs (mean number of new lesions per subject) · Patients undergoing fixed orthodontic treatment with fixed (multibracket) appliances, followed for development of new ICLs
Patients developed on average about 2.29 new ICLs during fixed orthodontic treatment (95% CI 1.12-3.46; very low certainty; very high heterogeneity).
1 finding from 1 review
Prevalence of ICLs (mean number of lesions per subject) · Patients (permanent dentition) during or after fixed orthodontic treatment with fixed (multibracket) appliances
Patients had on average about 2.24 ICLs per subject during/after fixed orthodontic treatment (95% CI 1.79-2.70; very low certainty; very high heterogeneity).
1 finding from 1 review
Incidence of new ICLs (proportion of tooth surfaces developing new lesions) · Patients undergoing fixed orthodontic treatment with fixed (multibracket) appliances, followed for development of new ICLs
About 15% of tooth surfaces developed new ICLs during fixed orthodontic treatment (pooled 0.15, 95% CI 0.08-0.26; very low certainty; extreme heterogeneity).
1 finding from 1 review
Association between orthodontic treatment duration and ICLs prevalence · Patients (permanent dentition) during or after fixed orthodontic treatment with fixed (multibracket) appliances
ICLs prevalence increased with longer orthodontic treatment duration (meta-regression P=.01; ungraded).
1 finding from 1 review
Association between patient age and number of ICLs · Patients (permanent dentition) during or after fixed orthodontic treatment with fixed (multibracket) appliances
Patient age was not significantly associated with the number of ICLs (ungraded).
1 finding from 1 review
Association between orthodontic treatment duration and ICLs incidence · Patients undergoing fixed orthodontic treatment with fixed (multibracket) appliances, followed for development of new ICLs
ICLs incidence increased with longer orthodontic treatment duration (meta-regression P<.01; ungraded).
1 finding from 1 review
Incidence of new ICLs (proportion of subjects developing new lesions) · Patients undergoing fixed orthodontic treatment with fixed (multibracket) appliances, followed for development of new ICLs
About 48% of patients developed new ICLs during fixed orthodontic treatment (pooled incidence 0.48, 95% CI 0.33-0.63; very low certainty; very high heterogeneity).
1 finding from 1 review
Prevalence of ICLs (proportion of tooth surfaces affected) · Patients (permanent dentition) during or after fixed orthodontic treatment with fixed (multibracket) appliances
About 22% of tooth surfaces showed ICLs during/after fixed orthodontic treatment (pooled 0.22, 95% CI 0.14-0.33; very low certainty; extreme heterogeneity).
1 finding from 1 review
Prevalence of ICLs (proportion of subjects affected) · Patients (permanent dentition) during or after fixed orthodontic treatment with fixed (multibracket) appliances
Around 57% of patients had ICLs during or after fixed orthodontic treatment (pooled prevalence 0.57, 95% CI 0.48-0.65; very low certainty; very high heterogeneity).
1 finding from 1 review