Findings

What do systematic reviews say?

127 questions · 175 findings · 35 reviews · All outcomes

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No studies found 46 · 26.3%GRADE not reported 96 · 54.9%Very low 21 · 12%Low 3 · 1.7%Moderate 9 · 5.1%High 0 · 0%

COE with blood/salivary (biomarker) analysis vs Conventional oral examination (COE) alone

Outcome not reported · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance programme, or screened…

The review found no eligible studies for this question.

1 finding from 1 review

Clinical assessment for the detection of oral cavity cancer and potentially malignant disorders in apparently healthy… 2021 · Cochrane All outcomes
No eligible studies; planned comparative analysis (COE vs COE with blood/salivary analysis) not populated in this version.
0 studies
No studies found

COE with vital rinsing (toluidine blue/tolonium chloride) vs Conventional oral examination (COE) alone

Sensitivity · Oral cavity cancer or potentially malignant disorder symptom-free individuals with tobacco habits

1 finding from 1 review

Clinical assessment for the detection of oral cavity cancer and potentially malignant disorders in apparently healthy… 2021 · Cochrane All outcomes
Sensitivity 0.40 [0.05, 0.85]
1 study · 4080 participants
Moderate

Bleaching gel with added remineralising agent (fluoride, calcium, or CPP-ACP) vs Bleaching alone (no remineralising agent)

Whitening (bleaching) efficacy · Demineralised / white-spot-lesion enamel (in vitro specimens)

Low-quality in vitro evidence indicates that adding fluoride or other remineralising agents does not impair the whitening/bleaching effect (ungraded).

1 finding from 1 review

Is Bleaching Effective in Managing Post-orthodontic White-spot Lesions? A Systematic Review. 2020 All outcomes
In vitro laboratory studies
Low-quality in vitro data indicated that the presence of fluoride or any other remineralising agent did not impair the whitening effect.
3 studies
GRADE not reported

Bleaching gel with added remineralising agent (fluoride, calcium, or CPP-ACP) vs Bleaching alone (no remineralising agent)

Enamel mineral loss / remineralisation · Demineralised / white-spot-lesion enamel (in vitro specimens)

Low-quality in vitro evidence indicates that adding fluoride, calcium or CPP-ACP to bleaching agents can reduce enamel mineral loss (ungraded).

1 finding from 1 review

Is Bleaching Effective in Managing Post-orthodontic White-spot Lesions? A Systematic Review. 2020 All outcomes
In vitro laboratory studies
Inconclusive: F/Ca/CPP-ACP additives reduced mineral loss on SOUND enamel (refs 8,10,16) but not verified for artificial caries lesions (ref 35)
4 studies
GRADE not reported

Er:YAG laser preparation combined with acid-etching vs Acid-etching (phosphoric acid)

Sealant retention rate (completely retained) · Children with permanent molars requiring pit-and-fissure sealants

At 12 months, Er:YAG laser combined with acid-etching significantly improved sealant retention versus acid-etching alone (OR 0.39, 95% CI 0.19 to 0.80, favouring laser+acid; ungraded, single study).

4 findings from 1 review

The clinical effects of laser preparation of tooth surfaces for fissure sealants placement: a systematic review and… 2019 All outcomes
12 months · Clinical (in vivo pit-and-fissure sealant placement)
OR 0.39 [0.19, 0.80]
1 study · 42 participants
GRADE not reported
The clinical effects of laser preparation of tooth surfaces for fissure sealants placement: a systematic review and… 2019 All outcomes
6 months · Clinical (in vivo pit-and-fissure sealant placement)
OR 0.55 [0.23, 1.34]
1 study · 42 participants
GRADE not reported
The clinical effects of laser preparation of tooth surfaces for fissure sealants placement: a systematic review and… 2019 All outcomes
18 months · Clinical (in vivo pit-and-fissure sealant placement)
OR 0.41 [0.21, 0.80]
1 study · 42 participants
GRADE not reported

Show 1 more finding

The clinical effects of laser preparation of tooth surfaces for fissure sealants placement: a systematic review and… 2019 All outcomes
3 months · Clinical (in vivo pit-and-fissure sealant placement)
OR 0.47 [0.14, 1.64]
1 study · 42 participants
GRADE not reported

Er:YAG laser preparation combined with acid-etching vs Acid-etching (phosphoric acid)

Physiological stress indicators (heart rate, oxygen saturation) · Children (ages 6-12) receiving pit-and-fissure sealants

Heart rate and oxygen saturation did not differ significantly between laser-plus-acid and acid-etching (ungraded, single study).

1 finding from 1 review

The clinical effects of laser preparation of tooth surfaces for fissure sealants placement: a systematic review and… 2019 All outcomes
Clinical (in vivo pit-and-fissure sealant placement)
Shindova 2018 (Er:YAG laser+acid vs acid-etching): no significant differences in heart rate or oxygen saturation between groups.
1 study · 64 participants
GRADE not reported

Er:YAG laser preparation combined with acid-etching vs Acid-etching (phosphoric acid)

Development of >=1 new carious lesion (caries incidence) · Children (high caries risk) with permanent molars requiring pit-and-fissure sealants

Caries incidence was 10% with laser-plus-acid versus 22% with acid-etching at 18 months, a non-significant difference (ungraded, single study).

1 finding from 1 review

The clinical effects of laser preparation of tooth surfaces for fissure sealants placement: a systematic review and… 2019 All outcomes
18 months · Clinical (in vivo pit-and-fissure sealant placement)
Durmus 2017 (Er:YAG laser+acid vs acid-etching): caries incidence 10% (n=8) in the laser-plus-acid group vs 22% (n=18) in the acid-etching group at 18 months; difference not statistically significant (P > 0.05).
1 study · 51 participants
GRADE not reported