Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

182 questions · 183 findings · 20 reviews · Headline outcomes only

No studies found 46 · 25.1%GRADE not reported 5 · 2.7%Very low 51 · 27.9%Low 37 · 20.2%Moderate 34 · 18.6%High 10 · 5.5%

Intervention not reported

50% reduction in tumour size · people with TSC

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Response to skin lesion · people with TSC

The intervention leads to higher response to skin lesion (high certainty).

1 finding from 1 review

Summary of findings table ‐ Psychological interventions vs inactive control (usual care care, attention control, waitlist)

Substance use ‐ post‐intervention ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

Summary of findings table ‐ Psychological interventions showed no clear difference in substance use ‐ post‐interventiong compared with inactive control (usual care care, attention control, waitlist) (low certainty).

1 finding from 1 review

Summary of findings table ‐ Psychological interventions vs inactive control (usual care care, attention control, waitlist)

Parent relationship quality ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood
1 finding from 1 review

Summary of findings table ‐ Psychological interventions vs inactive control (usual care care, attention control, waitlist)

Parental self‐harm ‐ post‐intervention ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Psychological interventions vs inactive control (usual care care, attention control, waitlist)

Parent‐child relationship or assessment of parenting · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

It is very uncertain whether summary of findings table ‐ Psychological interventions changes parent–child relationship ‐ post‐interventionm compared with inactive control (usual care care, attention control, waitlist) (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Service system approaches vs inactive control (usual care care, attention control, waitlist)

Trauma‐related symptoms ‐ post‐intervention ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Service system approaches vs inactive control (usual care care, attention control, waitlist)

Psychological well‐being (secondary outcome) Not addressed · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood
1 finding from 1 review

Summary of findings table ‐ Service system approaches vs inactive control (usual care care, attention control, waitlist)

Substance use ‐ post‐intervention ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Service system approaches vs inactive control (usual care care, attention control, waitlist)

Parent relationship quality ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Service system approaches vs inactive control (usual care care, attention control, waitlist)

Parental self‐harm ‐ post‐intervention ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Service system approaches vs inactive control (usual care care, attention control, waitlist)

Parent–child relationship ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Service system approaches vs inactive control (usual care care, attention control, waitlist)

Parenting skills; postintervention · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Parenting interventions vs inactive control (usual care care, attention control, waitlist)

Substance use ‐ post‐intervention ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Parenting interventions vs inactive control (usual care care, attention control, waitlist)

Parent relationship quality ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Parenting interventions vs inactive control (usual care care, attention control, waitlist)

Parental self‐harm ‐ post‐intervention ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review