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Evidence found and GRADE certainty

191 questions · 192 findings · 22 reviews

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No studies found 47 · 24.5%GRADE not reported 5 · 2.6%Very low 57 · 29.7%Low 39 · 20.3%Moderate 34 · 17.7%High 10 · 5.2%

Intervention not reported

FEV1/FVC ratio · people with TSC

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse events · people with TSC

The intervention probably leads to higher adverse events (moderate certainty).

1 finding from 1 review

Intervention not reported

Response to skin lesionsb · people with TSC

The intervention leads to higher response to skin lesionsb (high certainty).

1 finding from 1 review

Intervention not reported

Frequency of seizure · people with TSC

The intervention probably leads to higher frequency of seizure (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of participants with an increased creatinine level · people with TSC

The intervention probably leads to lower number of participants with an increased creatinine level (moderate certainty).

1 finding from 1 review

Intervention not reported

FEV1/FVC ratio · people with TSC

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse events · people with TSC

The intervention leads to higher adverse events (high certainty).

1 finding from 1 review

Intervention not reported

50% reduction in tumour size · people with TSC

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Response to skin lesion · people with TSC

The intervention leads to higher response to skin lesion (high certainty).

1 finding from 1 review

Summary of findings table ‐ Psychological interventions vs inactive control (usual care care, attention control, waitlist)

Substance use ‐ post‐intervention ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

Summary of findings table ‐ Psychological interventions showed no clear difference in substance use ‐ post‐interventiong compared with inactive control (usual care care, attention control, waitlist) (low certainty).

1 finding from 1 review

Summary of findings table ‐ Psychological interventions vs inactive control (usual care care, attention control, waitlist)

Parent relationship quality ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood
1 finding from 1 review

Summary of findings table ‐ Psychological interventions vs inactive control (usual care care, attention control, waitlist)

Parental self‐harm ‐ post‐intervention ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Psychological interventions vs inactive control (usual care care, attention control, waitlist)

Parent‐child relationship or assessment of parenting · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

It is very uncertain whether summary of findings table ‐ Psychological interventions changes parent–child relationship ‐ post‐interventionm compared with inactive control (usual care care, attention control, waitlist) (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Service system approaches vs inactive control (usual care care, attention control, waitlist)

Trauma‐related symptoms ‐ post‐intervention ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Service system approaches vs inactive control (usual care care, attention control, waitlist)

Psychological well‐being (secondary outcome) Not addressed · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood
1 finding from 1 review

Summary of findings table ‐ Service system approaches vs inactive control (usual care care, attention control, waitlist)

Substance use ‐ post‐intervention ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review