Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

154 questions · 163 findings · 21 reviews

No studies found 18 · 11%GRADE not reported 2 · 1.2%Very low 27 · 16.6%Low 61 · 37.4%Moderate 51 · 31.3%High 4 · 2.5%

Effects of different inhaled corticosteroids on growth in children with persistent asthma: fluticasone vs budesonide

Linear growth velocity (cm/year) · children up to 18 years of age with persistent asthma

It is very uncertain whether effects of different inhaled corticosteroids on growth in children… changes linear growth velocity (cm/year) compared with budesonide (very low certainty).

1 finding from 1 review

Effects of different inhaled corticosteroids on growth in children with persistent asthma: fluticasone vs budesonide

Change in height · children up to 18 years of age with persistent asthma

Effects of different inhaled corticosteroids on growth in children… probably leads to higher change in height (cm) over a period of time compared with budesonide (moderate certainty).

1 finding from 1 review

Mesalamine (4 ‐ 4.5 g/day) vs budesonide

Induction of clinical remission (CDAI < or = 150) · patients with Induction of remission or response in Crohn's disease

Mesalamine (4 ‐ 4.5 g/day) may leads to lower induction of remission (CDAI < or = 150) ‐ Pentasa (4 g/day) compared with budesonide (low certainty).

2 findings from 1 review

Capsaicin vs budesonide

Nasal obstruction during the 4th week of treatment Number of responders · patients with non‐allergic rhinitis

Capsaicin showed no clear difference in nasal obstruction during the 4th week of treatment Number of… compared with budesonide (low certainty).

1 finding from 1 review

Capsaicin vs budesonide

Treatment‐related adverse events · patients with non‐allergic rhinitis

The review found no eligible studies for this question.

1 finding from 1 review

160/4.5 mcg BDF single inhaler therapy vs current best practice

Hospital admissions due to exacerbations: number of participants · adults with asthma not well controlled on ICS

160/4.5 mcg BDF single inhaler therapy showed no clear difference in patients with exacerbations causing hospitalisation compared with current best practice (low certainty).

1 finding from 1 review