Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

202 questions · 207 findings · 17 reviews · Headline outcomes only

No studies found 23 · 11.1%GRADE not reported 32 · 15.5%Very low 61 · 29.5%Low 64 · 30.9%Moderate 18 · 8.7%High 9 · 4.3%

Summary of findings table ‐ Lignocaine vs benzodiazepines

Proportion of infants who achieve seizure control after maximal loading dose of ASM · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Lignocaine changes proportion of infants who achieve seizure control after maximal… compared with benzodiazepines (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Lignocaine vs benzodiazepines

Mortality or neurodevelopmental disability at 12 months · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Lignocaine changes mortality or neurodevelopmental disability at 12 months compared with benzodiazepines (very low certainty).

1 finding from 1 review

MDAC + hospital intervention vs hospital intervention

Incidence of mortality · first aid in patients with acute oral poisoning (benzodiazepines, yellow oleander or combinations of different drugs)

MDAC + hospital intervention showed no clear difference in incidence of mortality compared with hospital intervention (low certainty).

1 finding from 1 review

MDAC + hospital intervention vs hospital intervention

Incidence of adverse events · first aid in patients with acute oral poisoning (benzodiazepines, yellow oleander or combinations of different drugs)

MDAC + hospital intervention showed no clear difference in incidence of adverse events compared with hospital intervention (low certainty).

1 finding from 1 review

MDAC + hospital intervention vs hospital intervention

Incidence and severity of symptoms of poisoning: incidence of need for intubation · first aid in patients with acute oral poisoning (benzodiazepines, yellow oleander or combinations of different drugs)

MDAC + hospital intervention showed no clear difference in incidence and severity of symptoms of poisoning: incidence of need… compared with hospital intervention (low certainty).

1 finding from 1 review

HALOPERIDOL + PROMETHAZINE vs lorazepam

Global state: Needing restraints or seclusion ‐ by 12 hours · people with psychosis‐induced aggression

HALOPERIDOL + PROMETHAZINE showed no clear difference in global state: Needing restraints or seclusion ‐ by 12 hours compared with BENZODIAZEPINES ‐ LORAZEPAM (moderate certainty).

1 finding from 1 review