Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

213 questions · 219 findings · 19 reviews

No studies found 25 · 11.4%GRADE not reported 33 · 15.1%Very low 70 · 32%Low 64 · 29.2%Moderate 18 · 8.2%High 9 · 4.1%

Summary of findings table ‐ Lignocaine vs benzodiazepines

Proportion of infants who achieve seizure control after maximal loading dose of ASM · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Lignocaine changes proportion of infants who achieve seizure control after maximal… compared with benzodiazepines (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Lignocaine vs benzodiazepines

Mortality or neurodevelopmental disability at 12 months · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Lignocaine changes mortality or neurodevelopmental disability at 12 months compared with benzodiazepines (very low certainty).

1 finding from 1 review

MDAC + hospital intervention vs hospital intervention

Incidence of mortality · first aid in patients with acute oral poisoning (benzodiazepines, yellow oleander or combinations of different drugs)

MDAC + hospital intervention showed no clear difference in incidence of mortality compared with hospital intervention (low certainty).

1 finding from 1 review

MDAC + hospital intervention vs hospital intervention

Incidence of adverse events · first aid in patients with acute oral poisoning (benzodiazepines, yellow oleander or combinations of different drugs)

MDAC + hospital intervention showed no clear difference in incidence of adverse events compared with hospital intervention (low certainty).

1 finding from 1 review

MDAC + hospital intervention vs hospital intervention

Incidence and severity of symptoms of poisoning: incidence of need for intubation · first aid in patients with acute oral poisoning (benzodiazepines, yellow oleander or combinations of different drugs)

MDAC + hospital intervention showed no clear difference in incidence and severity of symptoms of poisoning: incidence of need… compared with hospital intervention (low certainty).

1 finding from 1 review