Early childhood caries (ECC) - association with genetically predicted expression of IGSF5 (chr21q22.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted IGSF5 expression reached the TWAS threshold for ECC (p = 7.22e-5) but was flagged as a possible false positive (LD misspecification) and not further considered; ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of LINC02905 (C8orf49) (chr8p23.1) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted LINC02905 (C8orf49) expression reached the TWAS threshold for ECC (p = 1.82e-8) but was flagged as a possible false positive (LD misspecification) and not further considered; ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of CDH17 (chr8q22.1) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of CDH17 was significantly associated with ECC in the TWAS (p = 3.32e-8); genetic association, ungraded.
1 finding from 1 review
Exacerbations (number of people experiencing ≥ 1 exacerbations) · patients with chronic obstructive pulmonary disease
Quinolone showed no clear difference in number of participants experiencing one or more exacerbations… compared with macrolide (low certainty).
1 finding from 1 review
Paina (scale from 0‐10, 0 is no pain) · people with impingement syndrome without full‐thickness rotator cuff tears
1 finding from 1 review
QoL · people with impingement syndrome without full‐thickness rotator cuff tears
1 finding from 1 review
Adverse events · people with impingement syndrome without full‐thickness rotator cuff tears
Subacromial decompression showed no clear difference in adverse events compared with exercises (moderate certainty).
1 finding from 1 review
Serious adverse events · people with impingement syndrome without full‐thickness rotator cuff tears
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Functional outcomes · people with impingement syndrome without full‐thickness rotator cuff tears
1 finding from 1 review
Global assessment of treatment success · people with impingement syndrome without full‐thickness rotator cuff tears
Subacromial decompression showed no clear difference in global assessment of treatment success compared with placebo surgery (moderate certainty).
1 finding from 1 review
Health status and quality of life · people with impingement syndrome without full‐thickness rotator cuff tears
1 finding from 1 review
Adverse events · people with impingement syndrome without full‐thickness rotator cuff tears
Subacromial decompression showed no clear difference in adverse events compared with placebo surgery (moderate certainty).
1 finding from 1 review
Serious adverse events · people with impingement syndrome without full‐thickness rotator cuff tears
1 finding from 1 review
Paina (scale from 0‐10, 0 is no pain) · people with impingement syndrome without full‐thickness rotator cuff tears
1 finding from 1 review
Functional outcomes · people with impingement syndrome without full‐thickness rotator cuff tears
1 finding from 1 review
Global assessment of treatment success · people with impingement syndrome without full‐thickness rotator cuff tears
Subacromial decompression showed no clear difference in global assessment of treatment success compared with exercises (low certainty).
1 finding from 1 review
All‐cause mortality · patients with chronic obstructive pulmonary disease
1 finding from 1 review
Quality of life Drug resistance/microbial sensitivity Serious adverse events Lung function Hospitalisations Adverse events/side effects Number of participants colonised with P aeruginosa · patients with chronic obstructive pulmonary disease
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Deaths · any indication
Other adverse events in people taking macrolide antibiotics showed no clear difference in deaths compared with placebo (low certainty).
1 finding from 1 review
Cardiac disorders · any indication
It is very uncertain whether other adverse events in people taking macrolide antibiotics changes cardiac disorders compared with placebo (very low certainty).
1 finding from 1 review