Findings

What do systematic reviews say?

1,655 questions · 1,751 findings · 147 reviews · Pain, Palliative and Supportive Care

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No studies found 361 · 20.6%GRADE not reported 87 · 5%Very low 625 · 35.7%Low 367 · 21%Moderate 232 · 13.2%High 79 · 4.5%

SSRIs or SNRIs vs placebo

Migraine intensity Score · patients for whom migraine preventive interventions are indicated

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 113 participants
Low

SSRIs or SNRIs vs placebo

Migraine duration Hours · patients for whom migraine preventive interventions are indicated

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
GRADE not reported

SSRIs or SNRIs vs placebo

Symptomatic/analgesic medication use for acute headache attacks · patients for whom migraine preventive interventions are indicated

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 113 participants
Low

SSRIs or SNRIs vs placebo

Migraine index · patients for whom migraine preventive interventions are indicated

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 86 participants
Very low

SSRIs or SNRIs vs placebo

Quality of life · patients for whom migraine preventive interventions are indicated

The review found no eligible studies for this question.

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

SSRIs or SNRIs vs placebo

Number withdrawn due to adverse events · patients for whom migraine preventive interventions are indicated

It is very uncertain whether SSRIs or SNRIs changes withdrawn (due to adverse events) compared with placebo (very low certainty).

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
OR 1.95 [0.7, 5.44]
5 studies · 221 participants
Very low

SSRIs or SNRIs vs amitriptyline

Migraine frequency Number of attacks · patients for whom migraine preventive interventions are indicated

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 96 participants
Very low

SSRIs or SNRIs vs amitriptyline

Migraine intensity Score · patients for whom migraine preventive interventions are indicated

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 104 participants
Low

VAS pain scores (0 to 100): PCA vs non‐patient controlled opioid analgesia

Pain scores 0 to 24 hVisual analog scaleScale from: 0 to 100 · patients with postoperative pain

1 finding from 1 review

Patient controlled opioid analgesia versus non‐patient controlled opioid analgesia for postoperative pain 2015 · Cochrane Headline outcomes only
no estimate extracted
23 studies · 1516 participants
Moderate

Patient satisfaction: PCA vs non‐patient controlled opioid analgesia

Number of patients in arm satisfied with therapy · patients with postoperative pain

1 finding from 1 review

Patient controlled opioid analgesia versus non‐patient controlled opioid analgesia for postoperative pain 2015 · Cochrane Headline outcomes only
no estimate extracted
11 studies · 547 participants
Low

VAS pain scores (0 to 100): PCA vs non‐patient controlled opioid analgesia

Pain scores 25 to 48 hVisual analog scaleScale from: 0 to 100 · patients with postoperative pain

1 finding from 1 review

Patient controlled opioid analgesia versus non‐patient controlled opioid analgesia for postoperative pain 2015 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 609 participants
Low

VAS pain scores (0 to 100): PCA vs non‐patient controlled opioid analgesia

Pain scores 49 to 72 hVisual analog scaleScale from: 0 to 100 · patients with postoperative pain

1 finding from 1 review

Patient controlled opioid analgesia versus non‐patient controlled opioid analgesia for postoperative pain 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 231 participants
Very low

VAS pain scores (0 to 100): PCA vs non‐patient controlled opioid analgesia

Pain scores 0 to 48 hVisual analog scaleScale from: 0 to 100 · patients with postoperative pain

1 finding from 1 review

Patient controlled opioid analgesia versus non‐patient controlled opioid analgesia for postoperative pain 2015 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 372 participants
Low

Consumption of intravenous morphine equivalents (mg): PCA vs non‐patient controlled opioid analgesia

Consumption of morphine equivalents 0 to 24 hmg · patients with postoperative pain

1 finding from 1 review

Patient controlled opioid analgesia versus non‐patient controlled opioid analgesia for postoperative pain 2015 · Cochrane Headline outcomes only
no estimate extracted
25 studies · 1586 participants
Low

Consumption of intravenous morphine equivalents (mg): PCA vs non‐patient controlled opioid analgesia

Consumption of morphine equivalents 25 to 48 hmg · patients with postoperative pain

1 finding from 1 review

Patient controlled opioid analgesia versus non‐patient controlled opioid analgesia for postoperative pain 2015 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 449 participants
Moderate

Consumption of intravenous morphine equivalents (mg): PCA vs non‐patient controlled opioid analgesia

Consumption of morphine equivalents 0 to 48 hmg · patients with postoperative pain

1 finding from 1 review

Patient controlled opioid analgesia versus non‐patient controlled opioid analgesia for postoperative pain 2015 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 334 participants
Very low

Consumption of intravenous morphine equivalents (mg): PCA vs non‐patient controlled opioid analgesia

Consumption of morphine equivalents 0 to 72 hmg · patients with postoperative pain

1 finding from 1 review

Patient controlled opioid analgesia versus non‐patient controlled opioid analgesia for postoperative pain 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 244 participants
Very low

Patient satisfaction: PCA vs non‐patient controlled opioid analgesia

Satisfaction on a continuous scale · patients with postoperative pain

1 finding from 1 review

Patient controlled opioid analgesia versus non‐patient controlled opioid analgesia for postoperative pain 2015 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 427 participants
Low

Intervention not reported

At least 50% of maximum pain relief over 4 to 6 hours · Adults with acute pain

The intervention leads to higher at least 50% of maximum pain relief over 4 to 6 hours (high certainty).

1 finding from 1 review

Single dose oral diclofenac for acute postoperative pain in adults 2015 · Cochrane Headline outcomes only
RR 3.7 [2.9, 4.7]
7 studies · 757 participants
High

Intervention not reported

Participants remedicating within 8 hours · Adults with acute pain

The intervention leads to lower participants remedicating within 8 hours (high certainty).

1 finding from 1 review

Single dose oral diclofenac for acute postoperative pain in adults 2015 · Cochrane Headline outcomes only
RR 0.5 [0.45, 0.6]
7 studies · 757 participants
High