Findings

What do systematic reviews say?

1,352 questions · 1,400 findings · 169 reviews

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No studies found 309 · 22.1%GRADE not reported 115 · 8.2%Very low 350 · 25%Low 324 · 23.1%Moderate 240 · 17.1%High 62 · 4.4%

Intervention not reported

Treatment failure at 1 month or less · patients with acute otitis media

The intervention showed no clear difference in treatment failure at 1 month or less; GRADE not reported.

1 finding from 1 review

Short‐course antibiotics for acute otitis media 2010 · Cochrane Headline outcomes only
OR 1.02 [0.87, 1.2]
19 studies · 4354 participants
GRADE not reported

Third generation cephalosporins vs conventional therapy

Death · patients treated for acute bacterial meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
19 studies · 1496 participants
GRADE not reported

Third generation cephalosporins vs conventional therapy

Death · patients treated for meningococcal meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 477 participants
GRADE not reported

Third generation cephalosporins vs conventional therapy

Deafness · patients treated for acute bacterial meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 501 participants
GRADE not reported

Third generation cephalosporins vs conventional therapy

Culture positivity 10 to 48 hours start of treatment · patients treated for acute bacterial meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
12 studies · 442 participants
GRADE not reported

Third generation cephalosporins vs conventional therapy

Diarrhoea · patients treated for acute bacterial meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
12 studies · 750 participants
GRADE not reported

Third generation cephalosporins vs conventional therapy

Neutropenia · patients treated for acute bacterial meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 472 participants
GRADE not reported

Third generation cephalosporins vs conventional therapy

Rash · patients treated for acute bacterial meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 533 participants
GRADE not reported

Third generation cephalosporins vs conventional therapy

Treatment failure (either death or deafness) · patients treated for acute bacterial meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
19 studies · 1496 participants
GRADE not reported

Cephalosporins vs conventional therapy

Death · patients treated for H. influenzae meningitis

1 finding from 1 review

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 318 participants
GRADE not reported

Antibiotics vs control ‐ primary outcomes

Prevention ‐ any AOM or CSOM during intervention · patients with the prevention of acute and chronic suppurative otitis media in children

Antibiotic probably leads to lower prevention ‐ any AOM or CSOM during intervention compared with control ‐ primary outcomes (moderate certainty).

1 finding from 1 review

Antibiotics for the prevention of acute and chronic suppurative otitis media in children 2006 · Cochrane Headline outcomes only
RR 0.65 [0.53, 0.79]
14 studies · 1461 participants
Moderate

Antibiotics vs control ‐ secondary outcomes

Side effects ‐ any clinical side effects during intervention · patients with the prevention of acute and chronic suppurative otitis media in children

Antibiotic showed no clear difference in side effects ‐ any clinical side effects during intervention compared with control ‐ secondary outcomes (moderate certainty).

1 finding from 1 review

Antibiotics for the prevention of acute and chronic suppurative otitis media in children 2006 · Cochrane Headline outcomes only
RR 1.99 [0.25, 15.89]
12 studies · 817 participants
Moderate