What do systematic reviews say?

Oxycodone vs placebo

• Oxycodone for pain in fibromyalgia in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Oxycodone vs placebo

• Oxycodone for pain in fibromyalgia in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Oxycodone vs placebo

• Oxycodone for pain in fibromyalgia in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Perioperative infraorbital nerve block vs Placebo (sham/placebo device)

• Infraorbital nerve block for postoperative pain following cleft lip repair in children 2016 · Cochrane All outcomes
  2 out of 3 studies reported this outcome. One study reported no differences between groups, and the other study reported more vomiting in the placebo group (Takmaz 2009: vomiting 40% placebo versus 10% intervention; P…
  2 studies
  GRADE not reported

Perioperative infraorbital nerve block vs Infiltration of the incision (peri-incisional infiltration)

• Infraorbital nerve block for postoperative pain following cleft lip repair in children 2016 · Cochrane All outcomes
  Gaonkar 2004: no differences between groups in postoperative heart rate and blood pressure. Prabhu 1999: significantly lower heart rates in the intervention group throughout the postoperative period, and no differences…
  2 studies
  GRADE not reported

Perioperative infraorbital nerve block vs Infiltration of the incision (peri-incisional infiltration)

The review found no eligible studies for this question.

• Infraorbital nerve block for postoperative pain following cleft lip repair in children 2016 · Cochrane All outcomes
  This outcome was not reported.
  0 studies
  No studies found

Perioperative infraorbital nerve block vs Placebo (sham/placebo device)

The review found no eligible studies for this question.

• Infraorbital nerve block for postoperative pain following cleft lip repair in children 2016 · Cochrane All outcomes
  None of the included studies reported this outcome.
  0 studies
  No studies found

Perioperative infraorbital nerve block vs Intravenous analgesia

The review found no eligible studies for this question.

• Infraorbital nerve block for postoperative pain following cleft lip repair in children 2016 · Cochrane All outcomes
  This outcome was not reported.
  0 studies
  No studies found

Perioperative infraorbital nerve block vs Infiltration of the incision (peri-incisional infiltration)

• Infraorbital nerve block for postoperative pain following cleft lip repair in children 2016 · Cochrane All outcomes
  Of the 2 included studies, one study reported no difference between groups (Gaonkar 2004: no adverse events attributable to either technique), and the other study did not report this outcome.
  1 study
  GRADE not reported

Perioperative infraorbital nerve block vs Intravenous analgesia

• Infraorbital nerve block for postoperative pain following cleft lip repair in children 2016 · Cochrane All outcomes
  Not pooled (lack of data). Delgado 2005: longer in the infraorbital block group (7.3 +/- 5.1 hours) versus intravenous analgesia (2.8 +/- 2.2 hours) (P < 0.01). Simion 2008: no significant difference (195.32 +/- 71.21…
  3 studies
  GRADE not reported

Pilocarpine vs placebo

• Parasympathomimetic drugs for the treatment of salivary gland dysfunction due to radiotherapy 2015 · Cochrane All outcomes
  Johnson 1993: positive response (>25 mm change in VAS score) in 25% of participants on placebo, 51% on pilocarpine 5 mg tds, 47% on pilocarpine 10 mg tds. LeVeque 1993: positive response in 7% on placebo vs 42% on…
  2 studies · 278 participants
  GRADE not reported

Parasympathomimetic drugs (choline esters, cholinesterase inhibitors) vs No treatment

The review found no eligible studies for this question.

• Parasympathomimetic drugs for the treatment of salivary gland dysfunction due to radiotherapy 2015 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Pilocarpine vs placebo

• Parasympathomimetic drugs for the treatment of salivary gland dysfunction due to radiotherapy 2015 · Cochrane All outcomes
  Both studies assessed oral discomfort and dysphonia (Johnson 1993; LeVeque 1993); pilocarpine reported to improve associated symptoms of salivary gland dysfunction (oral discomfort, dysphonia). No pooled data.
  2 studies · 278 participants
  GRADE not reported

Pilocarpine vs placebo

• Parasympathomimetic drugs for the treatment of salivary gland dysfunction due to radiotherapy 2015 · Cochrane All outcomes
  Only two studies measured salivary flow rates (Johnson 1993; LeVeque 1993); no usable summary/pooled data reported.
  2 studies
  GRADE not reported

SSRIs or SNRIs vs placebo

• Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 113 participants
  Low

SSRIs or SNRIs vs amitriptyline

• Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 104 participants
  Low

SSRIs or SNRIs vs amitriptyline

The review found no eligible studies for this question.

• Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

SSRIs or SNRIs vs amitriptyline

• Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 62 participants
  Very low

SSRIs or SNRIs vs amitriptyline

The review found no eligible studies for this question.

• Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

SSRIs or SNRIs vs amitriptyline

SSRIs or SNRIs showed no clear difference in withdrawn (for any reasons and due to adverse events) compared with amitriptyline (low certainty).

• Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
  OR 0.39 [0.1, 1.5]
  1 study · 64 participants
  Low