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Evidence found and GRADE certainty

4,315 questions · 23,557 findings · 2,311 reviews

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No studies found 4,183 · 17.8%GRADE not reported 3,930 · 16.7%Very low 5,371 · 22.8%Low 5,787 · 24.6%Moderate 3,320 · 14.1%High 966 · 4.1%

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Replacement of the defective restoration vs Repair of the defective restoration

Amalgam: Preference for replacement over repair - Scenario 7: non-stable (mobile) restoration · Dentists managing a defective direct amalgam restoration (posterior occlusal Class I; standardized vignette of a 30-year-old,…

For a defective amalgam restoration with non-stable (mobile) restoration, surveyed dentists most often preferred replacement over repair (pooled RR 24.22; p < 0.001); ungraded.

1 finding from 1 review

Replacement of the defective restoration vs Repair of the defective restoration

Composite: Preference for replacement over repair - Scenario 7: non-stable (mobile) restoration · Dentists managing a defective direct resin composite restoration (posterior occlusal Class I; standardized vignette of a 30-year-old,…

For a defective composite restoration with non-stable (mobile) restoration, surveyed dentists most often preferred replacement over repair (pooled RR 12.17; p < 0.001); ungraded.

1 finding from 1 review

Dental caries vs Caries-free controls

Periodontitis (prevalence) · adults

Using adjusted ORs, caries remained associated with higher periodontitis odds (OR 1.57).

3 findings from 1 review

Overweight/obesity (combined) vs Normal Weight or Non‐Obese

Dental caries prevalence · Brazilian children/adolescents in permanent dentition (BMI classified by CDC 2000 growth charts)

The evidence is very uncertain about the effect of overweight/obesity on caries odds in the permanent dentition (very low certainty).

1 finding from 1 review

Periodontitis vs No periodontitis (periodontal health or gingivitis)

Dental caries prevalence · adults

With a non-standard periodontitis definition, the association persisted (OR 1.38).

12 findings from 1 review
Show 9 more findings

Ate or licked fluoride toothpaste vs Did not eat or lick fluoride toothpaste

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years
1 finding from 1 review
  • Topical fluoride as a cause of dental fluorosis in children 2024 · Cochrane All outcomes
    Fluorosis assessed when most permanent teeth of interest had erupted (6 to 18 years)
    Nine studies investigated whether children ate or licked toothpaste; measurement subjective so not meta-analyzed (Table 1). Findings mixed: some studies found no significant difference; others (e.g. Celeste 2016 OR up…
    9 studies
    GRADE not reported

Brushed less than once per day vs Brushed once or more per day

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years

Brushed less than once per day may leads to lower fluorosis (percentage prevalence in permanent teeth) compared with brushed once or more per day (low certainty).

1 finding from 1 review

Fluoride varnish applied before 4 years of age vs Non-fluoride (placebo) varnish

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years

Fluoride varnish applied before 4 years of age (biannual) showed no clear difference in fluorosis (percentage prevalence in permanent teeth) compared with placebo varnish (low certainty).

1 finding from 1 review

Used fluoride mouth rinse vs No fluoride mouth rinse

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years

Used fluoride mouth rinse showed no clear difference in fluorosis (percentage prevalence in permanent teeth) compared with no fluoride mouth rinse; GRADE not reported.

1 finding from 1 review

Teledentistry diagnosis using DSLR or smartphone extra-oral photographs vs Visual or clinical examination

Positive predictive value for dental caries diagnosis · Children and adults with primary or permanent dentition

Positive predictive values were reported in 10 of the 13 studies that reported sensitivity and specificity; no meta-analysis or GRADE rating was reported.

1 finding from 1 review

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

Depression · People with temporomandibular disorders (TMD)

Occlusal splint showed no clear difference in depression compared with physical therapy (ultrasound, exercise, sensorimotor training,…; GRADE not reported.

1 finding from 1 review