Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,550 questions · 1,617 findings · 161 reviews · Neonatal

No studies found 238 · 14.7%GRADE not reported 76 · 4.7%Very low 377 · 23.3%Low 567 · 35.1%Moderate 285 · 17.6%High 74 · 4.6%

Morphine vs buprenorphine

Adverse events (treatment related) To discharge · newborn infants with opioid withdrawal

It is very uncertain whether morphine changes adverse events (treatment‐related) To discharge compared with buprenorphine (very low certainty).

1 finding from 1 review

Intervention not reported

Mortality by hospital discharge · preterm infants less than 30 weeks' gestational age requiring conventional mechanical ventilation for respiratory distress syndrome

The intervention showed no clear difference in mortality by hospital discharge (low certainty).

1 finding from 1 review

Intervention not reported

Incidence of bronchopulmonary dysplasia · preterm infants less than 30 weeks' gestational age requiring conventional mechanical ventilation for respiratory distress syndrome

The intervention showed no clear difference in incidence of bronchopulmonary dysplasia (low certainty).

1 finding from 1 review

Intervention not reported

Duration of neonatal intensive care unit stay (hours or days) · preterm infants less than 30 weeks' gestational age requiring conventional mechanical ventilation for respiratory distress syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Restricted vs standard fluid management

Incidence of hypernatremia (serum sodium > 145 mEq/L) at end of intervention period (proportions) · late preterm and full‐term infants with transient tachypnea of the newborn

It is very uncertain whether restricted changes incidence of hypernatremia (serum sodium > 145 mEq/L) at end of… compared with standard fluid management (very low certainty).

1 finding from 1 review

Restricted vs standard fluid management

Incidence of hypoglycemia (blood glucose < 40 mg/dL) at end of intervention period (proportions) · late preterm and full‐term infants with transient tachypnea of the newborn

It is very uncertain whether restricted changes incidence of hypoglycemia (blood glucose < 40 mg/dL) at end of… compared with standard fluid management (very low certainty).

1 finding from 1 review

Restricted vs standard fluid management

Incidence of endotracheal ventilation (proportions) during hospital stay (for infants on no support or noninvasive support at the time of study entry) · late preterm and full‐term infants with transient tachypnea of the newborn

It is very uncertain whether restricted changes incidence of endotracheal ventilation (proportions) during hospital… compared with standard fluid management (very low certainty).

1 finding from 1 review

Restricted vs standard fluid management

Incidence of noninvasive (nasal CPAP or nasal ventilation) respiratory support during hospital stay · late preterm and full‐term infants with transient tachypnea of the newborn

It is very uncertain whether restricted changes incidence of noninvasive (nasal CPAP or nasal ventilation)… compared with standard fluid management (very low certainty).

1 finding from 1 review