Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,234 questions · 3,357 findings · 396 reviews

No studies found 803 · 23.9%GRADE not reported 270 · 8%Very low 757 · 22.5%Low 859 · 25.6%Moderate 486 · 14.5%High 182 · 5.4%

Herbal medicines vs antibiotics alone

Remission · participants with acne

Herbal medicine showed no clear difference in secondary outcome: number of participants with remission (ITT‐best… compared with antibiotics (low certainty).

2 findings from 1 review

Uterine artery embolization (UAE) vs surgery

Adverse events: minor post‐procedural complications within one year · patients with symptomatic uterine fibroids

Uterine artery embolization (UAE) probably leads to higher adverse events: minor post‐procedural complications within one year compared with surgery (moderate certainty).

1 finding from 1 review

Interventions to reduce blood loss during myomectomy for fibroids vs placebo or no treatment

Fibrin sealant patch (collagen sponge with thrombin and fibrinogen) · women with uterine fibroids

Interventions to reduce blood loss during myomectomy for fibroids showed no clear difference in fibrin sealant patch (collagen sponge with thrombin and fibrinogen) compared with placebo or no treatment (low certainty).

1 finding from 1 review

Interventions to reduce blood loss during myomectomy for fibroids vs placebo or no treatment

Dinoprostone (prostaglandin E2 analogue) · women with uterine fibroids

Interventions to reduce blood loss during myomectomy for fibroids showed no clear difference in dinoprostone (prostaglandin E2 analogue) compared with placebo or no treatment (low certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs conventional therapy

Adverse events (episodes of peritonitis) ‐ treated with an aminoglycoside · patients receiving PD

Angiotensin‐converting enzyme inhibitors (ACEi) showed no clear difference in adverse events (episodes of peritonitis) ‐ treated with an… compared with conventional therapy (moderate certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs conventional therapy

Adverse events (episodes of peritonitis) ‐ not treated with an aminoglycoside · patients receiving PD

Angiotensin‐converting enzyme inhibitors (ACEi) showed no clear difference in adverse events (episodes of peritonitis) ‐ not treated with an… compared with conventional therapy (moderate certainty).

1 finding from 1 review

Intensive glycaemic control vs conventional glucose control

Progression of retinopathy · persons with type 1 diabetes mellitus

Intensive glucose control probably leads to lower progression of retinopathy compared with conventional glucose control (moderate certainty).

2 findings from 1 review

Thalidomide (systemic; 100 mg or 300 mg daily) vs placebo

Number of (minor aphthous) oral ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes
    Males only
    Hamuryudan 1998 (thalidomide 100 mg or 300 mg daily vs placebo, 101 male patients; high risk of reporting bias): a significant effect on mean numbers of minor oral ulcers was reported from week 4 in both thalidomide…
    1 study · 101 participants
    GRADE not reported

Intervention not reported

Serum concentrations ‐ aminoglycoside antibiotics: peak concentration · patients with leading serum concentrations within therapeutic range
1 finding from 1 review

Intervention not reported

Aminoglycoside antibiotics ‐ nephrotoxicity · patients with leading to fewer clinical adverse events

The intervention showed no clear difference in aminoglycoside antibiotics ‐ nephrotoxicity (low certainty).

1 finding from 1 review

Intervention not reported

Proportion of participants within therapeutic range ‐ aminoglycoside antibiotics: % of participants with peak concentrations adequate after 2 days · patients with leading serum concentrations within therapeutic range

The intervention probably leads to higher proportion of participants within therapeutic range ‐ aminoglycoside… (moderate certainty).

1 finding from 1 review

Intervention not reported

Maximum voluntary contraction in dystrophinopathies % · patients with muscular dystrophies
1 finding from 1 review

Intervention not reported

Abdominoperineal excision of the rectum rate ‐ Rectal cancer · Patients with outcomes after colorectal cancer surgery

It is very uncertain whether the intervention changes abdominoperineal excision of the rectum rate ‐ Rectal cancer (very low certainty).

1 finding from 1 review

Intervention not reported

Abdominoperineal excision of rectum rate ‐ Rectal cancer · Patients with outcomes after colorectal cancer surgery

It is very uncertain whether the intervention changes abdominoperineal excision of rectum rate ‐ Rectal cancer (very low certainty).

1 finding from 1 review