Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,661 questions · 2,751 findings · 453 reviews

No studies found 593 · 21.6%GRADE not reported 277 · 10.1%Very low 538 · 19.6%Low 712 · 25.9%Moderate 516 · 18.8%High 115 · 4.2%

Exercise therapy vs a control strategy (no treatment, placebo or waiting list controls)

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients with patellofemoral pain syndrome (symptoms > 3 weeks (1 study); symptoms > 1 month (3 studies); symptoms > 2 months (2 studies);…

It is very uncertain whether exercise therapy changes usual pain (long‐term) VAS (0 to 10; higher scores mean worse pain) compared with a control strategy (no treatment, placebo or waiting list controls) (very low certainty).

1 finding from 1 review

High‐intensity vs low‐intensity exercise programmes

Functional ability · patients with patellofemoral pain syndrome (untreated PFPS of over 2 months in duration)

It is very uncertain whether high‐intensity changes functional ability (long‐term) FIQ modified (0 to 16; higher scores… compared with low‐intensity exercise programmes (very low certainty).

1 finding from 1 review

Exercise therapy vs a control strategy (no treatment, placebo or waiting list controls)

Functional ability · patients with patellofemoral pain syndrome (symptoms > 3 weeks (1 study); symptoms > 1 month (3 studies); symptoms > 2 months (2 studies);…

It is very uncertain whether exercise therapy changes functional ability (long‐term) Scale (0 to 100; higher scores mean… compared with a control strategy (no treatment, placebo or waiting list controls) (very low certainty).

1 finding from 1 review

Exercise therapy vs a control strategy (no treatment, placebo or waiting list controls)

Recovered · patients with patellofemoral pain syndrome (symptoms > 3 weeks (1 study); symptoms > 1 month (3 studies); symptoms > 2 months (2 studies);…

It is very uncertain whether exercise therapy changes recovery (long‐term) Number of patients who had recovered or number… compared with a control strategy (no treatment, placebo or waiting list controls) (very low certainty).

1 finding from 1 review

Intervention not reported

Change in long‐term disability more than 3 months after the intervention Measure:6MWT · People with multiple sclerosis
1 finding from 1 review

Intervention not reported

Change in long‐term impairments more than 3 months after the intervention Measures: FIS, FSS · People with multiple sclerosis
1 finding from 1 review

Summary of findings table ‐ Prothrombin complex concentrates vs any comparator

Mortality within the longest · patients with vitamin K antagonist‐induced bleeding requiring acute intervention

It is very uncertain whether prothrombin complex concentrate changes overall mortality ‐ longest compared with any comparator (very low certainty).

1 finding from 1 review

Psychological interventions (positive and negative reinforcement) vs no treatment

Sucking cessation (long term) · Children with a non-nutritive sucking habit (digit or pacifier)

Psychological interventions (positive and negative reinforcement) led to higher sucking cessation (long term) compared with no treatment; GRADE not reported.

1 finding from 1 review

Psychological intervention (positive reinforcement) vs Alternative psychological intervention (negative reinforcement)

Sucking cessation (long term) · Children with a non-nutritive sucking habit (digit or pacifier)
1 finding from 1 review