Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,763 questions · 1,835 findings · 201 reviews · Headline outcomes only

No studies found 414 · 22.6%GRADE not reported 51 · 2.8%Very low 570 · 31.1%Low 468 · 25.5%Moderate 272 · 14.8%High 60 · 3.3%

Antioxidants vs placebo

Muscle soreness · mainly physically active individuals1 partaking in exercise2 designed to produce delayed onset muscle soreness

Summary of findings: antioxidants showed no clear difference in muscle soreness compared with placebo (low certainty).

5 findings from 1 review
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High‐intensity vs low‐intensity exercise programmes

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients with patellofemoral pain syndrome (untreated PFPS of over 2 months in duration)

It is very uncertain whether high‐intensity changes usual pain (short‐term) VAS (0 to 10; higher scores mean worse pain) compared with low‐intensity exercise programmes (very low certainty).

2 findings from 1 review

High‐intensity vs low‐intensity exercise programmes

Functional ability · patients with patellofemoral pain syndrome (untreated PFPS of over 2 months in duration)

It is very uncertain whether high‐intensity changes functional ability (short‐term) FIQ modified (0 to 16; higher scores… compared with low‐intensity exercise programmes (very low certainty).

2 findings from 1 review

Summary of findings: whole‐body cryotherapy (WBC) vs control (no WBC or passive rest)

Muscle pain at rest · physically‐active adults partaking in exercise designed to produce delayed onset muscle soreness (most trial participants were male)

It is very uncertain whether summary of findings: whole‐body cryotherapy (WBC) changes muscle soreness: pain at rest (VAS) compared with control (no WBC or passive rest) (very low certainty).

4 findings from 1 review
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Summary of findings: whole‐body cryotherapy (WBC) vs control (no WBC or passive rest)

Adverse events · physically‐active adults partaking in exercise designed to produce delayed onset muscle soreness (most trial participants were male)

The review found no eligible studies for this question.

1 finding from 1 review