Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,545 questions · 2,661 findings · 317 reviews

No studies found 608 · 22.8%GRADE not reported 505 · 19%Very low 695 · 26.1%Low 540 · 20.3%Moderate 249 · 9.4%High 64 · 2.4%

Mifepristone (all doses) vs Yuzpe

Observed number of pregnancies (all women) · women seeking emergency contraception

Mifepristone (all doses) leads to lower observed number of pregnancies (all women) compared with yuzpe (high certainty).

1 finding from 1 review

Mifepristone (all doses) vs Yuzpe

Abdominal pain · women seeking emergency contraception

Mifepristone (all doses) probably leads to lower specific side effects ‐ abdominal pain compared with yuzpe (moderate certainty).

1 finding from 1 review

Antibiotics vs no intervention

Serological cure (4‐fold decrease or greater in non‐treponemal tests titre) · newborns with congenital syphilis

Antibiotic treatment may leads to higher serological cure (≥ 4‐fold decrease in non‐treponemal tests titre) compared with no intervention (low certainty).

1 finding from 1 review

Endovascular revascularisation plus conservative therapy vs conservative therapy

Secondary invasive interventions · intermittent claudication

Endovascular revascularisation plus conservative therapy leads to lower secondary invasive interventions compared with conservative therapy alone (high certainty).

1 finding from 1 review

Standard care plus IV tranexamic acid vs placebo or usual care

Hysterectomy to control bleeding · women with primary postpartum haemorrhage following vaginal or caesarean birth

Standard care plus IV tranexamic acid showed no clear difference in surgical intervention to control bleeding: Hysterectomy compared with placebo or standard care alone (high certainty).

1 finding from 1 review

Standard care plus IV tranexamic acid vs placebo or usual care

Side effects of the intervention: Any maternal vascular occlusive event · women with primary postpartum haemorrhage following vaginal or caesarean birth

Standard care plus IV tranexamic acid showed no clear difference in side effects of the intervention: Any maternal vascular occlusive… compared with placebo or standard care alone (moderate certainty).

1 finding from 1 review

Thiopentone and ketamine vs benzodiazepines

Awareness Postoperative interview · patients with prevention of recall of events during surgery

It is very uncertain whether thiopentone and ketamine changes awareness Postoperative interview compared with benzodiazepines (diazepam, midazolam, lorazepam) (very low certainty).

1 finding from 1 review

Thiopentone and ketamine vs benzodiazepines

Adverse effects of intraoperative wakefulness and/or postoperative awareness (i.e. post‐traumatic stress syndrome, myocardial infarction, cardiac arrest, etc.) · patients with prevention of recall of events during surgery

The review found no eligible studies for this question.

1 finding from 1 review

Single full-coverage metal-ceramic crown over composite core and post vs Direct adhesive composite restoration with post (conventional filling, no crown)

Cost of the intervention · People with a permanent tooth that has undergone endodontic (root canal) treatment

The review found no eligible studies for this question.

1 finding from 1 review