Severe late complications · women with locally advanced cervical cancer
Hysterectomy (simple or radical) with chemoradiotherapy may leads to higher severe late complications compared with internal radiotherapy (brachytherapy) with chemoradiotherapy (low certainty).
1 finding from 1 review
Death (all causes) · women with locally advanced cervical cancer
Hysterectomy (simple or radical) with radiotherapy showed no clear difference in overall survival Median compared with radiotherapy alone (low certainty).
1 finding from 1 review
Survival ‐ · adults (aged 18+) with colorectal cancer
Adjunctive Coriolus versicolor may leads to higher survival ‐ compared with no adjunctive treatment (low certainty).
1 finding from 1 review
Withdrawals due to adverse events · adults (aged 18+) with colorectal cancer
It is very uncertain whether adjunctive Coriolus versicolor changes withdrawal from treatment due to adverse events ‐ compared with no adjunctive treatment (very low certainty).
1 finding from 1 review
Adverse events: Oral cavity disorders (includes oral dryness and mucositis)‐ · adults (aged 18+) with colorectal cancer
It is very uncertain whether adjunctive Coriolus versicolor changes adverse events: Oral cavity disorders (includes oral dryness and… compared with no adjunctive treatment (very low certainty).
1 finding from 1 review
Adverse events: nausea · adults (aged 18+) with colorectal cancer
It is very uncertain whether adjunctive Coriolus versicolor changes adverse events: Nausea ‐ compared with no adjunctive treatment (very low certainty).
1 finding from 1 review
Diarrhoea · adults (aged 18+) with colorectal cancer
It is very uncertain whether adjunctive Coriolus versicolor changes adverse events: Diarrhoea ‐ compared with no adjunctive treatment (very low certainty).
1 finding from 1 review
Adverse events: Neutrophils decreased ‐ · adults (aged 18+) with colorectal cancer
It is very uncertain whether adjunctive Coriolus versicolor changes adverse events: Neutrophils decreased ‐ compared with no adjunctive treatment (very low certainty).
1 finding from 1 review
Adverse effect: fatigue · adults (aged 18+) with colorectal cancer
It is very uncertain whether adjunctive Coriolus versicolor changes adverse events: Fatigue ‐ compared with no adjunctive treatment (very low certainty).
1 finding from 1 review
Locoregional control · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
Concomitant (concurrent) chemoradiotherapy led to lower locoregional control, concurrent chemoradiotherapy (platinum +… compared with radiotherapy alone (non-resectable tumours); GRADE not reported.
1 finding from 1 review
RR 0.75 [0.61, 0.93]
3 studies
GRADE not reported
All‐cause mortality: 1‐year overall survival · people with resectable cholangiocarcinoma
It is very uncertain whether adjuvant S‐1 changes all‐cause mortality: 1‐year overall survival compared with gemcitabine (very low certainty).
1 finding from 1 review
All‐cause mortality: 2‐year overall survival · people with resectable cholangiocarcinoma
It is very uncertain whether adjuvant S‐1 changes all‐cause mortality: 2‐year overall survival compared with gemcitabine (very low certainty).
1 finding from 1 review
Serious adverse events · people with resectable cholangiocarcinoma
1 finding from 1 review
Intervention not reported
All‐cause mortality · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…
The intervention showed no clear difference in all‐cause mortality (low certainty).
1 finding from 1 review
Intervention not reported
Relapsec · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…
The intervention probably leads to higher relapsec (moderate certainty).
1 finding from 1 review
Intervention not reported
Serious adverse events · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…
It is very uncertain whether the intervention changes serious adverse events (very low certainty).
1 finding from 1 review
Intervention not reported
Adverse events · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…
The intervention showed no clear difference in adverse events (moderate certainty).
1 finding from 1 review
Disease-free survival · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
Concomitant (concurrent) chemoradiotherapy led to lower disease-free survival, concurrent chemoradiotherapy vs radiotherapy… compared with radiotherapy alone (non-resectable tumours); GRADE not reported.
1 finding from 1 review
HR 0.74 [0.67, 0.80]
13 studies
GRADE not reported
Overall survival, adjuvant concomitant chemoradiotherapy vs post-surgery radiotherapy alone · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
Concomitant (concurrent) chemoradiotherapy probably leads to lower overall survival, concurrent chemoradiotherapy vs radiotherapy alone… compared with radiotherapy alone (non-resectable tumours) (moderate certainty).
1 finding from 1 review
Intervention not reported
Intervention: radiotherapy Comparison: no adjuvant treatment Outcome: neurocognitive impairment at 5‐ to 6‐year · people with glioma surviving at least two years
It is very uncertain whether the intervention changes intervention: radiotherapy Comparison: no adjuvant treatment… (very low certainty).
1 finding from 1 review