Cochrane · systematic review · CD012053
Coriolus (Trametes) versicolor mushroom to reduce adverse effects from chemotherapy or radiotherapy in people with colorectal cancer
Pilkington, K, Wieland, LS, Teng, L, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
ColorectalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 6 · 85.7%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Adjunctive Coriolus versicolor compared to no adjunctive treatment for colorectal cancer treatment
Population: adults (aged 18+) with colorectal cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Survival ‐ Adjunctive Coriolus versicolor vs no adjunctive treatment | RR 1.08 [1.01, 1.15] | 3 studies · 1094 participants | Low Downgraded: imprecision, indirectness |
Withdrawal from treatment due to adverse events ‐ Adjunctive Coriolus versicolor vs no adjunctive treatment | RR 1.03 [0.45, 2.34] | 3 studies · 703 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Adverse events: Oral cavity disorders (includes oral dryness and mucositis)‐ Adjunctive Coriolus versicolor vs no adjunctive treatment | RR 0.37 [0.13, 1.03] | 5 studies · 1022 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Adverse events: Nausea ‐ Adjunctive Coriolus versicolor vs no adjunctive treatment | RR 0.73 [0.44, 1.22] | 4 studies · 969 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Adverse events: Diarrhoea ‐ Adjunctive Coriolus versicolor vs no adjunctive treatment | RR 0.77 [0.32, 1.86] | 5 studies · 1022 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Adverse events: Neutrophils decreased ‐ Adjunctive Coriolus versicolor vs no adjunctive treatment | RR 0.41 [0.24, 0.71] | 3 studies · 133 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Adverse events: Fatigue ‐ Adjunctive Coriolus versicolor vs no adjunctive treatment | RR 0.76 [0.33, 1.78] | 3 studies · 133 participants | Very low Downgraded: risk of bias, imprecision, indirectness |