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Evidence found and GRADE certainty

2,745 questions · 4,389 findings · 203 reviews · Dental caries

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No studies found 39 · 0.9%GRADE not reported 3,844 · 87.6%Very low 198 · 4.5%Low 137 · 3.1%Moderate 134 · 3.1%High 37 · 0.8%

Hall technique vs Fluoride varnish

Treatment success (caries lesion arrest or restoration survival) · Children (aged 3-11 y) with cavitated caries lesions in primary teeth

At 12 months, the Hall technique had significantly higher treatment success than sodium fluoride varnish (OR 6.38; moderate certainty).

2 findings from 1 review

Ion-releasing restorations (IRR): RMGIC, HVGIC, GIC, compomer/PMRC, giomer vs Composite resin (CR), including bulk-fill composite

Absence of marginal discoloration · Children receiving dental restorations (aged 4-11 years; primary teeth; Class I/II/V cavities)

No significant difference between IRR and CR in marginal discoloration (moderate certainty; downgraded for inconsistency).

1 finding from 1 review

Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No cavity liner or a different liner material

Postoperative hypersensitivity (POH), patient-reported (VAS score) · Patients with deep caries lesions in mature or immature permanent (posterior) teeth, with no symptoms or reversible pulpitis

The evidence is very uncertain whether cavity liners reduce postoperative hypersensitivity; no significant difference was found overall (very low certainty).

1 finding from 1 review

Intervention not reported

Composite: Preference for replacement over repair - Scenario 7: non-stable (mobile) restoration

The intervention led to higher composite: Preference for replacement over repair - Scenario 7:…; GRADE not reported.

1 finding from 1 review

Quantitative light-induced fluorescence (QLF) vs Reference standard (histology; some ICDAS/radiography)

Proximal caries detection: sensitivity · Extracted human teeth (in vitro); permanent teeth, proximal (approximal) surfaces

In vitro, QLF pooled sensitivity for proximal caries detection was 0.83 (3 permanent-teeth studies; no primary-dentition data; ungraded).

1 finding from 1 review

Country-level income inequality (Gini index) vs Lower vs higher income inequality categories

Oral health-related quality of life · people aged 60 years and older living in the community

Older adults in countries with relative income equality (low Gini index) had markedly higher OHRQoL (91.3, 95% CI 90.0 to 92.6) than those in less equal countries; the difference by Gini index was statistically significant (ungraded).

4 findings from 1 review
Show 1 more finding

Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS

Osteoporosis with pathological fracture · European GWAS participants

The SVMR MR-Egger interval included the null.

3 findings from 1 review

Intervention not reported

Composite: Preference for replacement over repair - Scenario 2: loss of dental hard substance adjacent to the restoration

The intervention showed no clear difference in composite: Preference for replacement over repair - Scenario 2: loss…; GRADE not reported.

1 finding from 1 review

Partial pulpotomy with permanent restoration after 7-14 days vs No comparator

Overall success (composite of clinical and radiographic success) · Adults aged 18 years or older with mature permanent teeth and carious pulp exposure

Permanent restoration after 7-14 days was associated with a pooled success rate of 73.6%.

1 finding from 1 review

Higher per-capita expenditure on dental health care vs Lower per-capita expenditure on dental health care (USD bands: $0-50 / $51-100 / >$100)

Caries experience (mean DMFT) · 12-year-old children across European countries (national/regional epidemiological surveys, 2011-2022)

Countries with higher per-capita dental expenditure had lower mean DMFT (>$100: 0.96; $51-100: 2.14; $0-50: 3.06) (Figure 4); not GRADE-rated.

3 findings from 1 review

Mesoporous silica (SiO2) vs Calcium-based agent

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, Silica vs Calcium showed no significant difference in 24 h bond strength (MD 1.964, 95% CI -5.802 to 9.730; Moderate certainty).

1 finding from 1 review

Composite resin vs Amalgam restoration

Restoration failure · Permanent posterior teeth (molars/premolars) receiving direct restoration

There was no statistically significant difference in failure risk between composite resin and amalgam restorations in permanent posterior teeth (pooled RR 0.96, 95% CI 0.68 to 1.34; 13 studies; not GRADE-rated, with very high heterogeneity, I2 = 97%).

1 finding from 1 review

Fluoride mouthrinse (0.05-0.32% sodium fluoride or amine fluoride) added to daily fluoride toothpaste vs Control: fluoride toothpaste alone, placebo mouthrinse + toothpaste, or non-fluoride (chlorhexidine) mouthrinse + toothpaste

Incidence of initial caries around brackets, aesthetic-zone teeth only · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)

When only aesthetic-zone teeth (incisors and canines) were considered, two studies reported a significant reduction in initial caries incidence favoring fluoride mouthrinse (ungraded, narrative; no pooled estimate).

1 finding from 1 review

Epilepsy (as exposure/condition) vs Healthy participants without epilepsy (control group)

Caries in primary teeth: dmft (3 years) · Children and adolescents with epilepsy

In children/adolescents, the dmft (primary teeth) index does not differ significantly with epilepsy (SMD 0.132, 95% CI -0.220 to 0.484, P = .463; ungraded subgroup).

1 finding from 1 review