Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

142 questions · 149 findings · 12 reviews · Pain, Palliative and Supportive Care

No studies found 44 · 29.5%GRADE not reported 15 · 10.1%Very low 34 · 22.8%Low 39 · 26.2%Moderate 14 · 9.4%High 3 · 2%

Perioperative infraorbital nerve block vs Infiltration of the incision (peri-incisional infiltration)

Heart rate, respiratory rate, and blood pressure · Children up to 13 years of age, undergoing cleft lip repair surgery
1 finding from 1 review

Perioperative infraorbital nerve block vs Infiltration of the incision (peri-incisional infiltration)

Adverse events · Children up to 13 years of age, undergoing cleft lip repair surgery
1 finding from 1 review

Perioperative infraorbital nerve block vs Intravenous analgesia

Analgesia durationTime duration from the end of surgery to the time of first analgesic consumption. Scale from: 0 to 100. · Children up to 13 years of age, undergoing cleft lip repair surgery
1 finding from 1 review

Laminectomy plus radiotherapy vs radiotherapy

Ambulation · adults with metastatic extradural spinal cord compression (single lesion, no prior radiotherapy, fit for surgery)

It is very uncertain whether laminectomy plus radiotherapy changes ambulation At four months compared with radiotherapy (very low certainty).

1 finding from 1 review

Laminectomy plus radiotherapy vs radiotherapy

Survival At four months · adults with metastatic extradural spinal cord compression (single lesion, no prior radiotherapy, fit for surgery)

It is very uncertain whether laminectomy plus radiotherapy changes survival At four months compared with radiotherapy (very low certainty).

1 finding from 1 review

Laminectomy plus radiotherapy vs radiotherapy

Reduced use of analgesics · adults with metastatic extradural spinal cord compression (single lesion, no prior radiotherapy, fit for surgery)

It is very uncertain whether laminectomy plus radiotherapy changes reduction in analgesic use compared with radiotherapy (very low certainty).

1 finding from 1 review

Laminectomy plus radiotherapy vs radiotherapy

Urinary continence One month after radiation · adults with metastatic extradural spinal cord compression (single lesion, no prior radiotherapy, fit for surgery)

It is very uncertain whether laminectomy plus radiotherapy changes urinary continence One month after treatment compared with radiotherapy (very low certainty).

1 finding from 1 review

Tramadol vs placebo

Additional analgesia required (escape analgesia) · children undergoing surgery

Tramadol may leads to lower number of patients requiring rescue analgesia (PACU) compared with placebo (low certainty).

1 finding from 1 review

Tramadol vs pethidine

Additional analgesia required (escape analgesia) · children undergoing surgery

It is very uncertain whether tramadol changes number of patients requiring rescue analgesia (PACU) compared with pethidine (very low certainty).

1 finding from 1 review

Tramadol vs pethidine

Proportion of participants with moderate to severe pain up to 6 hours after the procedure · children undergoing surgery

Tramadol showed no clear difference in number of patients with moderate to severe pain (PACU) compared with pethidine (low certainty).

1 finding from 1 review

Tramadol vs pethidine

Number of patients with PONV (PACU) · children undergoing surgery

Tramadol showed no clear difference in number of patients with PONV (PACU) compared with pethidine (low certainty).

1 finding from 1 review

Tramadol vs fentanyl

Proportion of participants with moderate to severe pain up to 6 hours after the procedure · children undergoing surgery

The review found no eligible studies for this question.

1 finding from 1 review