Adverse events · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…
1 finding from 1 review
The majority of adverse events were minor in nature and usually included nausea, vomiting, headaches and dizziness. Side effect profiles have not been included in a meta-analysis as multiple adverse events were…
2 studies
GRADE not reported
Participant‐reported pain relief of 50% or greater · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…
Combined paracetamol plus ibuprofen in a single tablet (e.g.… probably leads to higher proportion of patients with >50% maximum pain relief (TOTPAR) over 6… compared with single drugs given separately (paracetamol 1000 mg or ibuprofen 400… (moderate certainty).
1 finding from 1 review
Patients not using rescue medication at 8 hours · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…
Combined paracetamol plus ibuprofen in a single tablet (e.g.… leads to higher patients not using rescue medication at 8 hours compared with single drugs given separately (paracetamol 1000 mg or ibuprofen 400… (high certainty).
1 finding from 1 review
Need for additional analgesia (4 hours after administration) · women with perineal pain in the early postpartum period
It is very uncertain whether NSAID (single administration, any dose) changes need for additional analgesia (4 hours after administration) compared with paracetamol (very low certainty).
1 finding from 1 review
Need for additional analgesia (6 hours after administration) · women with perineal pain in the early postpartum period
NSAID (single administration, any dose) may leads to lower need for additional analgesia (6 hours after administration) compared with paracetamol (low certainty).
1 finding from 1 review
Maternal drug adverse effects number of women experiencing adverse effects · women with perineal pain in the early postpartum period
1 finding from 1 review
Maternal drug adverse effects (6 hours after administration) · women with perineal pain in the early postpartum period
It is very uncertain whether NSAID (single administration, any dose) changes maternal drug adverse effects (6 hours after administration) compared with paracetamol (very low certainty).
1 finding from 1 review
Neonatal drug adverse effects ‐ not reported · women with perineal pain in the early postpartum period
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Relief of pain · women with perineal pain in the early postpartum period
NSAID (single administration, any dose) may leads to higher adequate pain relief (4 hours after administration) compared with paracetamol (low certainty).
2 findings from 1 review
Anastomotic leak · patients with Bowel resection
It is very uncertain whether single layer gastrointestinal anastomosis changes anastomotic leak Odds ratio compared with double layer gastrointestinal anastomosis (very low certainty).
1 finding from 1 review
Anastomosis time Mean difference · patients with Bowel resection
1 finding from 1 review
Hospital length of stay (high‐risk surgical patients) · patients with Bowel resection
1 finding from 1 review
Mortality Odds ratio · patients with Bowel resection
Single layer gastrointestinal anastomosis showed no clear difference in mortality Odds ratio compared with double layer gastrointestinal anastomosis (low certainty).
1 finding from 1 review
Major complications · patients with Bowel resection
Single layer gastrointestinal anastomosis showed no clear difference in major complications Odds ratio compared with double layer gastrointestinal anastomosis (low certainty).
1 finding from 1 review
Anastomotic leak in high quality trials Odds ratio · patients with Bowel resection
Single layer gastrointestinal anastomosis showed no clear difference in anastomotic leak in high quality trials Odds ratio compared with double layer gastrointestinal anastomosis (moderate certainty).
1 finding from 1 review
Anastomotic leak in poor quality trials Odds ratio · patients with Bowel resection
It is very uncertain whether single layer gastrointestinal anastomosis changes anastomotic leak in poor quality trials Odds ratio compared with double layer gastrointestinal anastomosis (very low certainty).
1 finding from 1 review
Overall survival (OS) · People with advanced non‐small cell lung cancer
Single‐immune checkpoint inhibitors (ICIs) probably leads to lower overall survival (OS) compared with chemotherapy (moderate certainty).
1 finding from 1 review
Progression‐free survival · People with advanced non‐small cell lung cancer
Single‐immune checkpoint inhibitors (ICIs) may leads to lower progression‐free survival (PFS) compared with chemotherapy (low certainty).
1 finding from 1 review
Overall response rate (ORR), · People with advanced non‐small cell lung cancer
Single‐immune checkpoint inhibitors (ICIs) may leads to higher overall response rate (ORR) compared with chemotherapy (low certainty).
1 finding from 1 review
Grades 3 and 4 adverse events · People with advanced non‐small cell lung cancer
Single‐immune checkpoint inhibitors (ICIs) may leads to lower adverse Events grade 3‐4 compared with chemotherapy (low certainty).
1 finding from 1 review