Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

625 questions · 647 findings · 67 reviews · Pregnancy and Childbirth

No studies found 83 · 12.8%GRADE not reported 70 · 10.8%Very low 141 · 21.8%Low 227 · 35.1%Moderate 97 · 15%High 29 · 4.5%

Probiotics vs placebo

Diagnosis of gestational diabetes · preventing gestational diabetes

Probiotics showed no clear difference in diagnosis of gestational diabetes mellitus compared with placebo (low certainty).

1 finding from 1 review

Probiotics vs placebo

Mortality or morbidity composite · preventing gestational diabetes

Probiotics showed no clear difference in mortality or morbidity composite compared with placebo (low certainty).

1 finding from 1 review

Probiotics vs placebo

Hypoglycaemia · preventing gestational diabetes

Probiotics showed no clear difference in hypoglycaemia as defined by trialists compared with placebo (low certainty).

1 finding from 1 review

Probiotics vs placebo

Hypertensive disorders of pregnancy: pre‐eclampsia · preventing gestational diabetes

Probiotics leads to higher hypertensive disorders of pregnancy (pre‐eclampsia) compared with placebo (high certainty).

1 finding from 1 review

Probiotics vs placebo

Large‐for‐gestational age · preventing gestational diabetes

Probiotics showed no clear difference in large‐for‐gestational age compared with placebo (moderate certainty).

1 finding from 1 review

Probiotics vs placebo

Perinatal mortality · preventing gestational diabetes

Probiotics showed no clear difference in perinatal mortality (stillbirth and neonatal mortality) compared with placebo (low certainty).

1 finding from 1 review

NSAIDs vs placebo

Adequate pain relief as reported by women · women with perineal pain in the early postpartum period

NSAID may leads to higher adequate pain relief(4 hours after administration) compared with placebo (low certainty).

2 findings from 1 review

NSAIDs vs placebo

Need for additional analgesia (6 hours after administration) · women with perineal pain in the early postpartum period

It is very uncertain whether NSAID changes need for additional analgesia (6 hours after administration) compared with placebo (very low certainty).

1 finding from 1 review