Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

298 questions · 307 findings · 39 reviews · Headline outcomes only

No studies found 46 · 15%GRADE not reported 4 · 1.3%Very low 97 · 31.6%Low 83 · 27%Moderate 57 · 18.6%High 20 · 6.5%

Percutaneous surgery plus steroid injection vs steroid injection

Adverse events (infection, partial loss of movement) · patients with trigger finger

It is very uncertain whether percutaneous surgery plus steroid injection changes adverse events (infection, partial loss of movement) compared with steroid injection (very low certainty).

1 finding from 1 review

Summary of findings. Surgery (percutaneous wire fixation) vs not surgery (cast only)

Physical function · children with displaced distal radius fracture with intact or involved or displaced ulna fracture (both‐bone fracture)

The review found no eligible studies for this question.

2 findings from 1 review

Summary of findings. Surgery (percutaneous wire fixation) vs not surgery (cast only)

'Treatment failure': various secondary procedures such as remanipulation for early loss of position; early or more complex wire removal ( · children with displaced distal radius fracture with intact or involved or displaced ulna fracture (both‐bone fracture)

It is very uncertain whether summary of findings. Surgery (percutaneous wire fixation) changes 'Treatment failure': various secondary procedures such as… compared with not surgery (cast only) (very low certainty).

1 finding from 1 review

Summary of findings. Surgery (percutaneous wire fixation) vs not surgery (cast only)

Serious adverse events (typically more serious complications) ( · children with displaced distal radius fracture with intact or involved or displaced ulna fracture (both‐bone fracture)

It is very uncertain whether summary of findings. Surgery (percutaneous wire fixation) changes serious adverse events (typically more serious complications) ( compared with not surgery (cast only) (very low certainty).

1 finding from 1 review

Summary of findings. Surgery (percutaneous wire fixation) vs not surgery (cast only)

Minor complications (less serious).j Here represented by referral for physical therapy for range of motion limitation (post‐immobilisation after 4 weeks) · children with displaced distal radius fracture with intact or involved or displaced ulna fracture (both‐bone fracture)

It is very uncertain whether summary of findings. Surgery (percutaneous wire fixation) changes minor complications (less serious).j Here represented by referral… compared with not surgery (cast only) (very low certainty).

1 finding from 1 review

Intervention not reported

Percutaneous transluminal coronary angioplasty · Free‐living adults who were healthy, had established cardiovascular disease or risk factors for cardiovascular disease

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Minimally invasive step‐up approach: planned surgery vs. continued percutaneous drainage · people with necrotising pancreatitis

It is very uncertain whether the intervention changes minimally invasive step‐up approach: planned surgery vs. continued… (very low certainty).

1 finding from 1 review

Intervention not reported

Co‐amoxiclav or cefotaxime versus placebo (percutaneous endoscopic gastrostomy) · surgical patients

It is very uncertain whether the intervention changes co‐amoxiclav or cefotaxime versus placebo (percutaneous endoscopic… (very low certainty).

1 finding from 1 review

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs placebo or usual care

Blood transfusion · Percutaneous nephrolithotomy

Topical TXA probably leads to lower blood transfusion compared with no TXA (placebo or usual care) (moderate certainty).

1 finding from 1 review

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs placebo or usual care

Stone‐free rate · Percutaneous nephrolithotomy

Topical TXA showed no clear difference in stone‐free rate compared with no TXA (placebo or usual care) (low certainty).

1 finding from 1 review

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs placebo or usual care

Thromboembolic events · Percutaneous nephrolithotomy

Topical TXA showed no clear difference in thromboembolic events compared with no TXA (placebo or usual care) (moderate certainty).

1 finding from 1 review