Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs placebo or usual care: Stone‐free rate
Topical TXA showed no clear difference in stone‐free rate compared with no TXA (placebo or usual care) (low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Topical TXA vs No TXA (placebo or usual care) Stone‐free rate · Percutaneous nephrolithotomy Topical TXA showed no clear difference in stone‐free rate compared with no TXA (placebo or usual care) (low certainty). Tranexamic acid for percutaneous nephrolithotomy (2023) · Cochrane Headline outcomes only | RR 1.07 [0.99, 1.17] | 1 study · 400 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Tranexamic acid for percutaneous nephrolithotomy 2023 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.