Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

140 questions · 145 findings · 33 reviews · Common Mental Disorders

No studies found 19 · 13.1%GRADE not reported 1 · 0.7%Very low 53 · 36.6%Low 41 · 28.3%Moderate 25 · 17.2%High 6 · 4.1%

Pharmacy‐based management (pharmacist with or without wider team) vs treatment

Acceptability of the intervention (as measured by participants not attending · adults

Pharmacy‐based management (pharmacist with or without wider team) showed no clear difference in acceptability of the intervention (as measured by participants not… compared with treatment (low certainty).

1 finding from 1 review

Intervention not reported

Acceptability of treatment (17 weeks) · women with a history of postnatal depression
1 finding from 1 review

Intervention not reported

Acceptability of treatment (17 weeks) · women with a history of postnatal depression
1 finding from 1 review

Client feedback vs no client feedback

Treatment acceptability: dropouts from treatment · children and adolescents, 11 to 18 years old, with mental health problems

It is very uncertain whether client feedback changes treatment acceptability: dropouts from treatment compared with no client feedback (very low certainty).

1 finding from 1 review

Topiramate as add‐on therapy vs placebo

Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with acute affective episodes in bipolar disorder

Topiramate as add‐on therapy showed no clear difference in acceptability with topiramate (endpoint: 12 weeks) Number of… compared with placebo (low certainty).

1 finding from 1 review

Topiramate as monotherapy vs alternative drug

Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with acute affective episodes in bipolar disorder

Topiramate as monotherapy showed no clear difference in acceptability with topiramate (12 weeks) Number of participants… compared with an alternative drug (low certainty).

1 finding from 1 review

Topiramate as add‐on therapy vs alternative drug

Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with acute affective episodes in bipolar disorder

It is very uncertain whether topiramate as add‐on therapy changes acceptability with topiramate (8 weeks) Number of participants… compared with alternative drug (very low certainty).

1 finding from 1 review

Topiramate vs placebo

Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with acute affective episodes in bipolar disorder

Topiramate showed no clear difference in acceptability with topiramate (endpoint: 12 weeks) Number of… compared with placebo (low certainty).

1 finding from 1 review

S‐adenosyl methionine as monotherapy vs tricyclic antidepressants (TCAs)

Acceptability. Participants experiencing troublesome adverse effects of any nature · depression in adults

S‐adenosyl methionine as monotherapy may leads to lower acceptability. Participants experiencing troublesome adverse effects… compared with tricyclic antidepressant agent (low certainty).

1 finding from 1 review

S‐adenosyl methionine as monotherapy vs tricyclic antidepressants (TCAs)

Secondary outcome: acceptability of treatment · depression in adults

It is very uncertain whether S‐adenosyl methionine as monotherapy changes acceptability Participants dropping out of treatment during the… compared with tricyclic antidepressant agent (very low certainty).

1 finding from 1 review

Paroxetine vs placebo

Secondary outcome: acceptability of treatment · people with anxiety and comorbid alcohol use disorders

It is very uncertain whether paroxetine changes treatment acceptability compared with placebo (very low certainty).

1 finding from 1 review

DCS and cognitive and behavioural therapies vs placebo and cognitive and behavioural therapies

Treatment withdrawal · adults with anxiety disorders

DCS and cognitive and behavioural therapies showed no clear difference in treatment acceptability: withdrawals from treatment compared with placebo and cognitive and behavioural therapies (moderate certainty).

1 finding from 1 review