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Evidence found and GRADE certainty

1,271 questions · 1,326 findings · 329 reviews

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No studies found 247 · 18.6%GRADE not reported 237 · 17.9%Very low 379 · 28.6%Low 285 · 21.5%Moderate 141 · 10.6%High 37 · 2.8%

Two or more foetal haemoglobin inducers at any dose or duration vs a usual management protocol, placebo or a single foetal haemoglobin inducer

Measures of HbF · people with non‐transfusion‐dependent β‐thalassaemia

The review found no eligible studies for this question.

1 finding from 1 review

Partial pulpotomy with permanent restoration after more than 14 days vs No comparator

Overall success (composite of clinical and radiographic success) · Adults aged 18 years or older with mature permanent teeth and carious pulp exposure

Permanent restoration after more than 14 days was associated with a pooled success rate of 23.2%.

1 finding from 1 review

Steroid therapy in first episode of nephrotic syndrome: 3 months or more vs 2 months of therapy

Frequent relapses · children with nephrotic syndrome

Steroid therapy in first episode of nephrotic syndrome: 3 months or… showed no clear difference in number with frequent relapses by 12 to 24 months compared with 2 months of therapy (moderate certainty).

1 finding from 1 review

Steroid therapy in first episode of nephrotic syndrome: 3 months or more vs 2 months of therapy

Number of children relapsing by 12 to 24 months · children with nephrotic syndrome

Steroid therapy in first episode of nephrotic syndrome: 3 months or… may leads to lower number of children relapsing by 12 to 24 months compared with 2 months of therapy (low certainty).

1 finding from 1 review

Steroid therapy in first episode of nephrotic syndrome: 3 months or more vs 2 months of therapy

Number with frequent relapses by 12 to 24 months stratified by risk of selection bias: Low risk of selection bias · children with nephrotic syndrome

Steroid therapy in first episode of nephrotic syndrome: 3 months or… showed no clear difference in number with frequent relapses by 12 to 24 months stratified by risk… compared with 2 months of therapy (high certainty).

1 finding from 1 review

Steroid therapy in first episode of nephrotic syndrome: 3 months or more vs 2 months of therapy

Number with frequent relapses by 12 to 24 months stratified by risk of bias for allocation concealment: unclear or high risk of bias for allocation bias · children with nephrotic syndrome

Steroid therapy in first episode of nephrotic syndrome: 3 months or… may leads to lower number with frequent relapses by 12 to 24 months stratified by risk… compared with 2 months of therapy (low certainty).

1 finding from 1 review

Steroid therapy in first episode of nephrotic syndrome: 3 months or more vs 2 months of therapy

Adverse events: psychological disorders · children with nephrotic syndrome

Steroid therapy in first episode of nephrotic syndrome: 3 months or… showed no clear difference in adverse events: psychological disorders compared with 2 months of therapy (low certainty).

1 finding from 1 review

Steroid therapy in first episode of nephrotic syndrome: 3 months or more vs 2 months of therapy

Adverse events: hypertension · children with nephrotic syndrome

Steroid therapy in first episode of nephrotic syndrome: 3 months or… showed no clear difference in adverse events: hypertension compared with 2 months of therapy (moderate certainty).

1 finding from 1 review

Steroid therapy in first episode of nephrotic syndrome: 3 months or more vs 2 months of therapy

Adverse events: Cushing's syndrome · children with nephrotic syndrome

Steroid therapy in first episode of nephrotic syndrome: 3 months or… showed no clear difference in adverse events: Cushing's syndrome compared with 2 months of therapy (moderate certainty).

1 finding from 1 review

Oral paracetamol vs placebo

At least 50% reduction in pain · Patients requiring surgical removal of a lower wisdom tooth or teeth, with baseline moderate to severe pain (surgery under local…

Paracetamol (single oral dose, any dose or formulation; subgroups up… led to higher achieving at least 50% pain relief at 4 hours (using pain intensity… compared with placebo; GRADE not reported.

3 findings from 1 review

Oral paracetamol vs placebo

Participant‐reported pain relief of 50% or greater · Patients requiring surgical removal of a lower wisdom tooth or teeth, with baseline moderate to severe pain (surgery under local…

Paracetamol (single oral dose, any dose or formulation; subgroups up… led to higher achieving at least 50% pain relief at 6 hours (using pain relief… compared with placebo; GRADE not reported.

1 finding from 1 review

Endodontic therapy (surgical or non-surgical) performed with the aid of one or more magnification devices (surgical microscope, endoscope or magnifying loupes) vs The same endodontic therapy performed without magnification devices (without visual enhancers)

Quality of root-end filling (retrograde/surgical treatment) · Patients of any age who received endodontic therapy and were followed up for at least 1 year after treatment

The review found no eligible studies for this question.

1 finding from 1 review
  • Magnification devices for endodontic therapy 2015 · Cochrane All outcomes
    No included study assessed this outcome; the review notes that such secondary outcomes were only sporadically reported and were never statistically assessed.
    Studies not reported
    No studies found

Endodontic therapy (surgical or non-surgical) performed with the aid of one or more magnification devices (surgical microscope, endoscope or magnifying loupes) vs The same endodontic therapy performed without magnification devices (without visual enhancers)

Removal of broken (fractured) instruments from the root canal · Patients of any age who received endodontic therapy and were followed up for at least 1 year after treatment

The review found no eligible studies for this question.

1 finding from 1 review
  • Magnification devices for endodontic therapy 2015 · Cochrane All outcomes
    No included study assessed this outcome; the review notes that such secondary outcomes were only sporadically reported and were never statistically assessed.
    Studies not reported
    No studies found