Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

163 questions · 167 findings · 14 reviews

No studies found 23 · 13.8%GRADE not reported 8 · 4.8%Very low 44 · 26.3%Low 65 · 38.9%Moderate 27 · 16.2%High 0 · 0%

Vaginal misoprostol vs placebo

Opiate use (as a proxy measure for pain) for all participants on ITT (including those without confirmed AMI) · early fetal death (less than 24 weeks)

It is very uncertain whether vaginal misoprostol changes pain (opiate use) compared with placebo (very low certainty).

1 finding from 1 review