Adverse events (all cause) · Men with COPD
Testosterone therapy showed no clear difference in adverse events (all cause) compared with placebo (low certainty).
1 finding from 1 review
Hospital admissions · Adults with acute asthma
Combination inhaled therapy probably leads to lower hospitalisation compared with SABA alone (moderate certainty).
1 finding from 1 review
Total adverse events · Adults with acute asthma
Combination inhaled therapy probably leads to higher total adverse events compared with SABA alone (moderate certainty).
1 finding from 1 review
FEV1 · Adults with acute asthma
1 finding from 1 review
Percent change FEV₁(%) · Adults with acute asthma
1 finding from 1 review
Health outcomes Peak expiratory flow readings (higher readings indicate better peak flow) · Adults with acute asthma
1 finding from 1 review
Change in PEF · Adults with acute asthma
1 finding from 1 review
Relapse · Adults with acute asthma
Combination inhaled therapy probably leads to lower relapse rates compared with SABA alone (moderate certainty).
1 finding from 1 review
Adherence to pharmacotherapy: number of people completing treatment · COPD
Single component intervention showed no clear difference in adherence to pharmacotherapy: number of people completing treatment compared with control (low certainty).
1 finding from 1 review
Adherence to pharmacotherapy: number of people achieving adherence to medication · COPD
Multi‐component intervention may leads to higher adherence to pharmacotherapy: number of people achieving adherence… compared with control (low certainty).
1 finding from 1 review
Overall treatment failure, including mortality, thoracic surgery or referral for further fibrinolytic therapy · adult parapneumonic effusions and empyema
Alteplase showed no clear difference in overall treatment failure, including mortality, thoracic surgery or… compared with urokinase (low certainty).
1 finding from 1 review
Overall treatment failure, including mortality, thoracic surgery or referral for further fibrinolytic therapy · adult parapneumonic effusions and empyema
It is very uncertain whether fibrinolytics changes overall treatment failure, including mortality, thoracic surgery or… compared with placebo (very low certainty).
1 finding from 1 review
Overall treatment failure, including mortality, thoracic surgery or referral for further fibrinolytic therapy · adult parapneumonic effusions and empyema
Streptokinase showed no clear difference in overall treatment failure, including mortality, thoracic surgery or… compared with urokinase (low certainty).
1 finding from 1 review
Children with progression of the disease resulting in additional medical therapy (complications) (measured as proportion of participants) · prolonged wet cough in children
Antibiotics probably leads to lower children with progression of the disease resulting in additional… compared with placebo (moderate certainty).
1 finding from 1 review
Treatment failure Need to intensify therapy/ED or hospital admission · exacerbations of COPD
Systemic corticosteroid leads to lower treatment failure Need to intensify therapy/ED or hospital admission compared with placebo (high certainty).
1 finding from 1 review
Treatment failure Need for additional treatment · exacerbations of COPD
Treatment route: intravenous corticosteroid showed no clear difference in treatment failure Need to intensify therapy compared with oral corticosteroid (moderate certainty).
1 finding from 1 review
Intervention not reported
Breathlessness ‐ all trials Lower score indicates improvement in breathlessness · patients with chronic obstructive pulmonary disease who do not qualify for home oxygen therapy
1 finding from 1 review
Intervention not reported
Breathlessness ‐ subgroup analysis ‐ studies using short‐burst oxygen Lower score indicates improvement in breathlessness · patients with chronic obstructive pulmonary disease who do not qualify for home oxygen therapy
1 finding from 1 review
Intervention not reported
Breathlessness ‐ subgroup analysis ‐ studies not using short‐burst oxygen Lower score indicates improvement in breathlessness · patients with chronic obstructive pulmonary disease who do not qualify for home oxygen therapy
1 finding from 1 review
Intervention not reported
Breathlessness ‐ subgroup analysis ‐ studies measuring during exercise test Lower score indicates improvement in breathlessness · patients with chronic obstructive pulmonary disease who do not qualify for home oxygen therapy
1 finding from 1 review