Quality of life · adults with metastatic extradural spinal cord compression (fit for surgery, paraplegic less than 48 hours, and without multiple discrete…
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Ambulation · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)
High‐dose corticosteroids showed no clear difference in ambulation compared with moderate‐dose or no corticosteroids (low certainty).
1 finding from 1 review
Reduction in analgesic and narcotic use One month after radiation · adults with metastatic extradural spinal cord compression (poor prognosis with visceral metastasis, and no spinal instability or bony…
Single‐fraction radiotherapy (8 Gy) showed no clear difference in reduction in analgesic and narcotic use One month after radiation compared with short‐course radiotherapy (16 Gy (moderate certainty).
1 finding from 1 review
Survival (long term) Over two years · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)
High‐dose corticosteroids showed no clear difference in survival (long term) Over two years compared with moderate‐dose or no corticosteroids (low certainty).
1 finding from 1 review
Pain reduction · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)
High‐dose corticosteroids showed no clear difference in pain reduction compared with moderate‐dose or no corticosteroids (low certainty).
1 finding from 1 review
Urinary continence One week after treatment · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)
High‐dose corticosteroids showed no clear difference in urinary continence One week after treatment compared with moderate‐dose or no corticosteroids (low certainty).
1 finding from 1 review
Local recurrence · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Serious adverse events · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)
High‐dose corticosteroids probably leads to higher serious adverse events compared with moderate‐dose or no corticosteroids (moderate certainty).
1 finding from 1 review
Quality of life · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Urinary continence One month after radiation · adults with metastatic extradural spinal cord compression (poor prognosis with visceral metastasis, and no spinal instability or bony…
Single‐fraction radiotherapy (8 Gy) showed no clear difference in urinary continence One month after radiation compared with short‐course radiotherapy (16 Gy (moderate certainty).
1 finding from 1 review
Local recurrence · adults with metastatic extradural spinal cord compression (poor prognosis with visceral metastasis, and no spinal instability or bony…
Single‐fraction radiotherapy (8 Gy) showed no clear difference in local recurrence MRI: compared with short‐course radiotherapy (16 Gy (low certainty).
1 finding from 1 review
Adverse events Grade 3 oesophagitis, diarrhoea and nausea · adults with metastatic extradural spinal cord compression (poor prognosis with visceral metastasis, and no spinal instability or bony…
Single‐fraction radiotherapy (8 Gy) showed no clear difference in adverse events Grade 3 oesophagitis, diarrhoea and nausea compared with short‐course radiotherapy (16 Gy (moderate certainty).
1 finding from 1 review
Quality of life · adults with metastatic extradural spinal cord compression (poor prognosis with visceral metastasis, and no spinal instability or bony…
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Ambulation · adults with metastatic extradural spinal cord compression (poor prognosis, no spinal instability or bony impingement of cord)
Split‐course radiotherapy (8 fractions, 30 Gy) showed no clear difference in ambulation One month after treatment compared with short‐course radiotherapy (2 fractions, 16 Gy) (moderate certainty).
1 finding from 1 review
Survival · adults with metastatic extradural spinal cord compression (poor prognosis, no spinal instability or bony impingement of cord)
1 finding from 1 review
Complete relief of pain · patients with metastatic bone pain
Radioisotopes probably leads to higher pain relief ‐ Complete relief compared with placebo (moderate certainty).
1 finding from 1 review
Pain relief ‐ Complete/Partial relief · patients with metastatic bone pain
Radioisotopes probably leads to higher pain relief ‐ Complete/Partial relief compared with placebo (moderate certainty).
1 finding from 1 review
Compression of spinal cord · patients with metastatic bone pain
Radioisotopes showed no clear difference in compression of spinal cord compared with placebo (low certainty).
1 finding from 1 review
Pain flares · patients with metastatic bone pain
Radioisotopes showed no clear difference in pain flares compared with placebo (low certainty).
1 finding from 1 review
Safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4 according to National Cancer Institute · patients with metastatic bone pain
Radioisotopes showed no clear difference in thrombocytopenia III‐IV compared with placebo (low certainty).
1 finding from 1 review