Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

315 questions · 326 findings · 28 reviews

No studies found 78 · 23.9%GRADE not reported 15 · 4.6%Very low 77 · 23.6%Low 76 · 23.3%Moderate 65 · 19.9%High 15 · 4.6%

IVIg vs no IVIG

Disease‐specific mortality ‐ SJS and TEN (time to · Stevens‐Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome

It is very uncertain whether intravenous immunoglobulin (IVIG) changes SJS/TEN‐specific mortality (time to compared with no IVIG (very low certainty).

1 finding from 1 review

Intervention not reported

Immunoglobulins (Direct evidence; 2 RCTs; 192 participants) · Patients with RRMS Interventions: alemtuzumab, azathriopine, cladribine, dimethylfumarate, fingolimod, glatiramer acetate,…

The intervention may leads to lower immunoglobulins (Direct evidence; 2 RCTs; 192 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Immunoglobulins (Direct evidence; 2 RCTs; 190 participants) · Patients with RRMS Interventions: Alemtuzumab, azathioprine, cladribine, dimethylfumarate, fingolimod, glatiramer acetate,…

It is very uncertain whether the intervention changes immunoglobulins (Direct evidence; 2 RCTs; 190 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Immunoglobulins (Direct evidence; 2 RCTs; 91 participants) · Patients with RRMS Interventions: Azathioprine, daclizumab, fingolimod, glatiramer acetate, Immunoglobulins, interferon beta 1a ‐1b,…

The intervention probably leads to lower immunoglobulins (Direct evidence; 2 RCTs; 91 participants) (moderate certainty).

1 finding from 1 review

Intervention not reported

Immunoglobulins (Direct evidence; 3 RCTs; 243 participants) · Patients with RRMS Interventions: Alemtuzumab, azathioprine, cladribine, daclizumab, dimethylfumarate, fingolimod, glatiramer acetate,…

It is very uncertain whether the intervention changes immunoglobulins (Direct evidence; 3 RCTs; 243 participants) (very low certainty).

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Salivary immunoglobulin A (SIgA) concentration · Children and adolescents (<18 years) living with HIV (CLWH)

Evidence on salivary IgA in CLWH on versus off ART was divergent and inconclusive (very low certainty).

1 finding from 1 review